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Molecules 2016, 21(2), 226; doi:10.3390/molecules21020226

Screening of Korean Natural Products for Anti-Adipogenesis Properties and Isolation of Kaempferol-3-O-rutinoside as a Potent Anti-Adipogenetic Compound from Solidago virgaurea

1
Department of Food Science and Nutrition, Hallym University, Okchon-dong, Chuncheon, Gangwon-do 200-702, Korea
2
Department of Boichemistry, Hallym University Medical School, Okchon-dong, Chuncheon, Gangwon-do 200-702, Korea
3
Institute of Natural Medicine, Hallym University, Okchon-dong, Chuncheon, Gangwon-do 200-702, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Rino Ragno
Received: 14 December 2015 / Revised: 6 February 2016 / Accepted: 9 February 2016 / Published: 17 February 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [5215 KB, uploaded 17 February 2016]   |  

Abstract

In this study, the anti-adipogenetic activity of 300 plant extracts was investigated using an Oil Red O staining assay in a 3T3-L1 cell line. Our results indicate that three plants, including the stem and leaf of Physalis angulata, the whole grass of Solidago virgaurea, and the root of Dioscorea nipponica, produced over 90% inhibition of adipogenesis. Kaempferol-3-O-rutinoside, which demonstrated a 48.2% inhibitory effect on adipogenesis without cytotoxicity, was isolated from the butanol layer of a water extract of S. virgaurea guided by the anti-adipogenesis assay in 3T3-L1. PPAR-γ and C/EBPα expression levels were determined using western blot, and our results indicate that kaempferol-3-O-rutinoside has a strong anti-adipogenic effect in 3T3-L1 cells through the suppression of increases in PPAR-γ and C/EBPα expression. View Full-Text
Keywords: obesity; screening; Solidago virgaurea; kaempferol-3-O-rutinoside obesity; screening; Solidago virgaurea; kaempferol-3-O-rutinoside
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jang, Y.S.; Wang, Z.; Lee, J.-M.; Lee, J.-Y.; Lim, S.S. Screening of Korean Natural Products for Anti-Adipogenesis Properties and Isolation of Kaempferol-3-O-rutinoside as a Potent Anti-Adipogenetic Compound from Solidago virgaurea. Molecules 2016, 21, 226.

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