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Molecules 2016, 21(12), 1613; doi:10.3390/molecules21121613

Multivalent Aptamers: Versatile Tools for Diagnostic and Therapeutic Applications

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Ave., 8, 630090 Novosibirsk, Russia
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Academic Editor: Harri Lönnberg
Received: 17 October 2016 / Revised: 11 November 2016 / Accepted: 18 November 2016 / Published: 25 November 2016
(This article belongs to the Special Issue Synthesis and Applications of Oligonucleotide Conjugates)
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Abstract

Nucleic acid aptamers generated through an in vitro selection are currently extensively applied as very valuable biomolecular tools thanks to their prominent advantages. Diversity of spatial structures, ease of production through chemical synthesis and a large variety of chemical modifications make aptamers convenient building blocks for the generation of multifunctional constructs. An opportunity to combine different aptamer functionalities with other molecules of interest such as reporter groups, nanoparticles, chemotherapeutic agents, siRNA or antisense oligonucleotides provides a widest range of applications of multivalent aptamers. The present review summarizes approaches to the design of multivalent aptamers, various examples of multifunctional constructs and the prospects of employing them as components of biosensors, probes for affinity capture, tools for cell research and potential therapeutic candidates. View Full-Text
Keywords: SELEX; aptamers; multivalency; design; conjugates; application SELEX; aptamers; multivalency; design; conjugates; application
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Vorobyeva, M.; Vorobjev, P.; Venyaminova, A. Multivalent Aptamers: Versatile Tools for Diagnostic and Therapeutic Applications. Molecules 2016, 21, 1613.

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