Next Article in Journal
Effects of Power Ultrasound on Stability of Cyanidin-3-glucoside Obtained from Blueberry
Next Article in Special Issue
In Vitro Chemopreventive Properties of Green Tea, Rooibos and Honeybush Extracts in Skin Cells
Previous Article in Journal
Ultrasound-Assisted Extraction May Not Be a Better Alternative Approach than Conventional Boiling for Extracting Polysaccharides from Herbal Medicines
Previous Article in Special Issue
Gallic Acid Content in Taiwanese Teas at Different Degrees of Fermentation and Its Antioxidant Activity by Inhibiting PKCδ Activation: In Vitro and in Silico Studies
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessReview
Molecules 2016, 21(11), 1566; doi:10.3390/molecules21111566

Biophysical Approach to Mechanisms of Cancer Prevention and Treatment with Green Tea Catechins

1
Graduate School of Science and Engineering, Saitama University, Shimo-okubo 255, Sakura-ku, Saitama 338-8570, Japan
2
Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Kitaadachi-gun, Saitama 362-0806, Japan
3
Saitama Prefectural Tea Research Institute, Kamiyaganuki 244-2, Iruma, Saitama 358-0042, Japan
4
Faculty of Medicine, Saga University, Nabeshima, Saga 849-8501, Japan
5
Department of Chemistry, Saitama University, Shimo-okubo 255, Sakura-ku, Saitama 338-8570, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 29 September 2016 / Revised: 26 October 2016 / Accepted: 9 November 2016 / Published: 18 November 2016
(This article belongs to the Special Issue Catechins and Human Health: Current State of the Science)
View Full-Text   |   Download PDF [2445 KB, uploaded 18 November 2016]   |  

Abstract

Green tea catechin and green tea extract are now recognized as non-toxic cancer preventives for humans. We first review our brief historical development of green tea cancer prevention. Based on exciting evidence that green tea catechin, (−)-epigallocatechin gallate (EGCG) in drinking water inhibited lung metastasis of B16 melanoma cells, we and other researchers have studied the inhibitory mechanisms of metastasis with green tea catechins using biomechanical tools, atomic force microscopy (AFM) and microfluidic optical stretcher. Specifically, determination of biophysical properties of cancer cells, low cell stiffness, and high deformability in relation to migration, along with biophysical effects, were studied by treatment with green tea catechins. The study with AFM revealed that low average values of Young’s moduli, indicating low cell stiffness, are closely associated with strong potential of cell migration and metastasis for various cancer cells. It is important to note that treatments with EGCG and green tea extract elevated the average values of Young’s moduli resulting in increased stiffness (large elasticity) of melanomas and various cancer cells. We discuss here the biophysical basis of multifunctions of green tea catechins and green tea extract leading to beneficial effects for cancer prevention and treatment. View Full-Text
Keywords: AFM; adhesion; durotaxis; EGCG; fluidity; membrane stiffness; metastasis; migration; rigidity; wound healing AFM; adhesion; durotaxis; EGCG; fluidity; membrane stiffness; metastasis; migration; rigidity; wound healing
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Suganuma, M.; Takahashi, A.; Watanabe, T.; Iida, K.; Matsuzaki, T.; Yoshikawa, H.Y.; Fujiki, H. Biophysical Approach to Mechanisms of Cancer Prevention and Treatment with Green Tea Catechins. Molecules 2016, 21, 1566.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top