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Molecules 2016, 21(11), 1538; doi:10.3390/molecules21111538

Comparison of Chemical Compositions in Pseudostellariae Radix from Different Cultivated Fields and Germplasms by NMR-Based Metabolomics

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 31 August 2016 / Revised: 7 November 2016 / Accepted: 9 November 2016 / Published: 15 November 2016
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Abstract

Pseudostellariae Radix (PR) is an important traditional Chinese medicine (TCM), which is consumed commonly for its positive health effects. However, the chemical differences of PR from different cultivated fields and germplasms are still unknown. In order to comprehensively compare the chemical compositions of PR from different cultivated fields, in this study, 1H-NMR-based metabolomics coupled with high performance liquid chromatography (HPLC) were used to investigate the different metabolites in PR from five germplasms (jr, zs1, zs2, sb, and xc) cultivated in traditional fields (Jurong, Jiangsu, JSJR) and cultivated fields (Zherong, Fujian, FJZR). A total of 34 metabolites were identified based on 1H-NMR data, and fourteen of them were found to be different in PR from JSJR and FJZR. The relative contents of alanine, lactate, lysine, taurine, sucrose, tyrosine, linolenic acid, γ-aminobutyrate, and hyperoside in PR from JSJR were higher than that in PR from FJZR, while PR from FJZR contained higher levels of glutamine, raffinose, xylose, unsaturated fatty acid, and formic acid. The contents of Heterophyllin A and Heterophyllin B were higher in PR from FJZR. This study will provide the basic information for exploring the influence law of ecological environment and germplasm genetic variation on metabolite biosynthesis of PR and its quality formation mechanism. View Full-Text
Keywords: Pseudostellariae Radix; 1H-NMR; metabolomics; cultivated fields; germplasms Pseudostellariae Radix; 1H-NMR; metabolomics; cultivated fields; germplasms
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MDPI and ACS Style

Hua, Y.; Hou, Y.; Wang, S.; Ma, Y.; Liu, Z.; Zou, L.; Liu, X.; Luo, Y.; Liu, J. Comparison of Chemical Compositions in Pseudostellariae Radix from Different Cultivated Fields and Germplasms by NMR-Based Metabolomics. Molecules 2016, 21, 1538.

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