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Molecules 2016, 21(1), 89; doi:10.3390/molecules21010089

Synthesis of Isotopically Labeled 13C3-Simazine and Development of a Simultaneous UPLC-MS/MS Method for the Analysis of Simazine in Soil

1
Plant Protection Institute of the Chinese Academy of Agricultural Sciences, Beijing 100193, China
2
College of Pharmacology, Ningxia Medical University, Yinchuan 750004, China
3
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 30 September 2015 / Revised: 21 December 2015 / Accepted: 6 January 2016 / Published: 14 January 2016
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [663 KB, uploaded 14 January 2016]   |  

Abstract

The isotope dilution mass spectrometry (IDMS) is a highly efficient method for tackling the ion suppression in complex matrix by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), but a lack of commercial internal standards is a limiting factor for these analyses. Herein, an economical and efficient strategy for the synthesis of 13C3-simazine via a three-step procedure was developed. The isotope-labeled internal standard was used for determination of simazine residue in soil samples. The quantitation method has a limit of detection of 0.015 μg/kg and quantitation of 0.08 μg/kg. The inter-day and intra-day precision of the method were below 4.6%. Recovery values were ranged between 92.9% and 99.2%. All the samples obtained from six provinces in China contained from 1 to 62 μg/kg of simazine. View Full-Text
Keywords: 13C3-simazine; synthesis; IDMS; UPLC-MS/MS; isotope labelling 13C3-simazine; synthesis; IDMS; UPLC-MS/MS; isotope labelling
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Song, Y.; Guo, Y.; Zhang, X.; Yang, Y.; Chen, S.; She, G.; She, D. Synthesis of Isotopically Labeled 13C3-Simazine and Development of a Simultaneous UPLC-MS/MS Method for the Analysis of Simazine in Soil. Molecules 2016, 21, 89.

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