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Molecules 2016, 21(1), 57; doi:10.3390/molecules21010057

Evaluation of the Nano-TiO2 as a Novel Deswelling Material

1
Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China
2
Key Laboratory of Medical Immunology, Ministry of Health, Beijing 100191, China
3
Pharmacy Department, Liao Ning University of Traditional Chinese Medicine, Shenyang 116600, Liao Ning, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Didier Astruc
Received: 26 September 2015 / Revised: 18 December 2015 / Accepted: 28 December 2015 / Published: 4 January 2016
(This article belongs to the Collection Nanomedicine)
View Full-Text   |   Download PDF [2598 KB, uploaded 4 January 2016]   |  

Abstract

Nano-TiO2 is widely applied in the automobile exhaust hose reels as a catalyst to reduce oxynitride emissions, including nitric oxide (NO). In the biomedicine field, NO plays an important role in vasodilation and edema formation in human bodies. However, the deswelling activity of nano-TiO2 has not been reported. Here, we demonstrated that nano-TiO2 can significantly degrade the production of NO in LPS-induced RAW264.7 mouse macrophages. Further study indicated that nano-TiO2 exhibited an effect on vascular permeability inhibition, and prevented carrageenan-induced footpad edema. Therefore, we prepared a nano-TiO2 ointment and observed similar deswelling effects. In conclusion, nano-TiO2 might act as a novel deswelling agent related with its degradation of NO, which will aid in our ability to design effective interventions for edema involved diseases. View Full-Text
Keywords: nano-TiO2; nitric oxide; deswelling activity; vascular permeability; nano-TiO2 ointment nano-TiO2; nitric oxide; deswelling activity; vascular permeability; nano-TiO2 ointment
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Chu, M.; Hou, Y.-L.; Xu, L.; Chu, Z.-Y.; Zhang, M.-B.; Wang, Y.-D. Evaluation of the Nano-TiO2 as a Novel Deswelling Material. Molecules 2016, 21, 57.

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