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Molecules 2016, 21(1), 14; doi:10.3390/molecules21010014

Cytotoxic and Antifungal Constituents Isolated from the Metabolites of Endophytic Fungus DO14 from Dendrobium officinale

1
Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang A & F University, Lin’an 311300, China
2
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
3
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 16 October 2015 / Revised: 18 November 2015 / Accepted: 27 November 2015 / Published: 22 December 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [2523 KB, uploaded 22 December 2015]   |  

Abstract

Two novel cytotoxic and antifungal constituents, (4S,6S)-6-[(1S,2R)-1, 2-dihydroxybutyl]-4-hydroxy-4-methoxytetrahydro-2H-pyran-2-one (1), (6S,2E)-6-hydroxy-3-methoxy-5-oxodec-2-enoic acid (2), together with three known compounds, LL-P880γ (3), LL-P880α (4), and Ergosta-5,7,22-trien-3b-ol (5) were isolated from the metabolites of endophytic fungi from Dendrobium officinale. The chemical structures were determined based on spectroscopic methods. All the isolated compounds 15 were evaluated by cytotoxicity and antifungal effects. Our present results indicated that compounds 14 showed notable anti-fungal activities (minimal inhibitory concentration (MIC) ≤ 50 μg/mL) for all the tested pathogens including Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, Aspergillus fumigatus. In addition, compounds 14 possessed notable cytotoxcities against human cancer cell lines of HL-60 cells with the IC50 values of below 100 μM. Besides, compounds 1, 2, 4 and 5 showed strong cytotoxities on the LOVO cell line with the IC50 values were lower than 100 μM. In conclusion, our study suggested that endophytic fungi of D. officinale are great potential resources to discover novel agents for preventing or treating pathogens and tumors. View Full-Text
Keywords: Dendrobium officinale; endophytic fungi; cytotoxic activities; antifungal activities; metabolites Dendrobium officinale; endophytic fungi; cytotoxic activities; antifungal activities; metabolites
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Wu, L.-S.; Jia, M.; Chen, L.; Zhu, B.; Dong, H.-X.; Si, J.-P.; Peng, W.; Han, T. Cytotoxic and Antifungal Constituents Isolated from the Metabolites of Endophytic Fungus DO14 from Dendrobium officinale. Molecules 2016, 21, 14.

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