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Molecules 2016, 21(1), 11; doi:10.3390/molecules21010011

New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl. (Cactaceae)

1
Post-Graduation Program in Development and Technological Innovation in Medicines, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900, Brazil
2
Post-Graduation Program in Bioactive Natural and Synthetic Products, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900 Brazil
3
Health Science Centre, Physiology and Pathology Department, Federal University of Paraiba, Campus I, Cidade Universitária—João Pessoa, PB, 58059-900, Brazil
4
Department of Agroecology and Agriculture, Center of Agricultural and Environmental Sciences, University of Paraiba State, 351 Baraúnas Street, Campina Grande, PB, 58429-500, Brazil
5
Postgraduate Program in Development and Technological Innovation in Medicines, Department of Molecular Sciences, Rural Federal University of Pernambuco, Campus Dois Irmãos, Recife, PE, 52171-900, Brazil
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Derek J. McPhee and John A. Beutler
Received: 19 October 2015 / Revised: 8 December 2015 / Accepted: 10 December 2015 / Published: 22 December 2015
(This article belongs to the Section Natural Products)
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Abstract

The Cactaceae family is composed by 124 genera and about 1438 species. Pilosocereus gounellei, popularly known in Brazil as xique-xique, is used in folk medicine to treat prostate inflammation, gastrointestinal and urinary diseases. The pioneering phytochemical study of P. gounellei was performed using column chromatography and HPLC, resulting in the isolation of 10 substances: pinostrobin (1), β-sitosterol (2), a mixture of sitosterol 3-O-β-d-glucopyranoside/stigmasterol 3-O-β-d-glucopyranoside (3a/3b), 132-hydroxyphaeophytin a (4), phaeophytin a (5), a mixture of β-sitosterol and stigmasterol (6a/6b), kaempferol (7), quercetin (8), 7′-ethoxy-trans-feruloyltyramine (mariannein, 9) and trans-feruloyl tyramine (10). Compound 9 is reported for the first time in the literature. The structural characterization of the compounds was performed by analyses of 1-D and 2-D NMR data. In addition, a phenolic and flavonol total content assay was carried out, and the anti-oxidant potential of P. gounellei was demonstrated. View Full-Text
Keywords: Pilosocereus gounellei; 7′-ethoxy-trans-feruloyltyramine; anti-oxidant activity Pilosocereus gounellei; 7′-ethoxy-trans-feruloyltyramine; anti-oxidant activity
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MDPI and ACS Style

Maciel, J.K.S.; Chaves, O.S.; Brito Filho, S.G.; Teles, Y.C.F.; Fernandes, M.G.; Assis, T.S.; Fernandes, P.D.; de Andrade, A.P.; Felix, L.P.; Silva, T.M.S.; Ramos, N.S.M.; Silva, G.R.; de Souza, M.F.V. New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl. (Cactaceae). Molecules 2016, 21, 11.

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