Dichlorinated and Brominated Rugulovasines, Ergot Alkaloids Produced by Talaromyces wortmannii
AbstractUHPLC-DAD-HRMS based dereplication guided the detection of new halogenated alkaloids co-produced by Talaromyces wortmannii. From the fungal growth in large scale, the epimers 2,8-dichlororugulovasines A and B were purified and further identified by means of a HPLC-SPE/NMR hyphenated system. Brominated rugulovasines were also detected when the microbial incubation medium was supplemented with bromine sources. Studies from 1D/2D NMR and HRMS spectroscopy data allowed the structural elucidation of the dichlorinated compounds, while tandem MS/HRMS data analysis supported the rationalization of brominated congeners. Preliminary genetic studies revealed evidence that FADH2 dependent halogenase can be involved in the biosynthesis of the produced halocompounds. View Full-Text
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de Medeiros, L.S.; da Silva, J.V.; Abreu, L.M.; Pfenning, L.H.; Silva, C.L.; Thomasi, S.S.; Venâncio, T.; van Pée, K.-H.; Nielsen, K.F.; Rodrigues-Filho, E. Dichlorinated and Brominated Rugulovasines, Ergot Alkaloids Produced by Talaromyces wortmannii. Molecules 2015, 20, 17627-17644.
de Medeiros LS, da Silva JV, Abreu LM, Pfenning LH, Silva CL, Thomasi SS, Venâncio T, van Pée K-H, Nielsen KF, Rodrigues-Filho E. Dichlorinated and Brominated Rugulovasines, Ergot Alkaloids Produced by Talaromyces wortmannii. Molecules. 2015; 20(9):17627-17644.Chicago/Turabian Style
de Medeiros, Lívia S.; da Silva, José V.; Abreu, Lucas M.; Pfenning, Ludwig H.; Silva, Carolina L.; Thomasi, Sérgio S.; Venâncio, Tiago; van Pée, Karl-Heinz; Nielsen, Kristian F.; Rodrigues-Filho, Edson. 2015. "Dichlorinated and Brominated Rugulovasines, Ergot Alkaloids Produced by Talaromyces wortmannii." Molecules 20, no. 9: 17627-17644.