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Molecules 2015, 20(9), 16924-16932; doi:10.3390/molecules200916924

Diterpenoids from the Endophytic Fungus Botryosphaeria sp. P483 of the Chinese Herbal Medicine Huperzia serrata

1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
2
School of Pharmaceutical Sciences, Kunming Medical University, Kunming 650500, China
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 16 July 2015 / Revised: 7 September 2015 / Accepted: 9 September 2015 / Published: 17 September 2015
(This article belongs to the Section Natural Products)
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Abstract

Two new tetranorlabdane diterpenoids, named botryosphaerins G (1) and H (2), were isolated from the solid fermentation products of Botryosphaeria sp. P483 along with seven known tetranorlabdane diterpenes (39). Their structures were elucidated by extensive analysis, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). Their absolute configuration was confirmed by single-crystal X-ray diffraction analyses using the anomalous scattering of Cu Kα radiation. All of the isolated compounds were tested for activity against phytopathogenic fungi and nematodes. Compounds 2 and 3 showed antifungal activity and compound 2 showed weak nematicidal activity. View Full-Text
Keywords: Botryosphaeria sp. P483; tetranorlabdane diterpenoid; X-ray crystallography; antifungal activity; nematicidal activity Botryosphaeria sp. P483; tetranorlabdane diterpenoid; X-ray crystallography; antifungal activity; nematicidal activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chen, Y.-M.; Yang, Y.-H.; Li, X.-N.; Zou, C.; Zhao, P.-J. Diterpenoids from the Endophytic Fungus Botryosphaeria sp. P483 of the Chinese Herbal Medicine Huperzia serrata. Molecules 2015, 20, 16924-16932.

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