Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities
AbstractA new skeleton of diterpenoid, 1,2,3,4,4α,9,10,10α-octahydro-(4α-hydroxyymethyl) -1,1-dimethyl-9-(1-methylethyl)-(2S,3S,4αR,9R,10αS)-2,3,5,7-phenanthrenetertrol, named plebeianiol A (1), along with four known diterpenoids (2–5), were isolated from Salvia plebeia R. Br. Their structures were determined on the basis of spectral analysis. In the bioactivity tests, compounds 1, 2 and 5 showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities with IC50 values of 20.0–29.6 µM. In addition, these three compounds had significant inhibitory effects on reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-induced macrophages. Compounds 1–3 inhibited nitric oxide (NO) production in LPS-induced macrophages with IC50 values of 18.0–23.6 µM. These results showed that compounds 1, 2 had significant antioxidant and anti-inflammatory activities and might provide basis for the treatment of diseases associated with oxidative lesions and inflammation. View Full-Text
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Zhang, B.-B.; He, B.-Q.; Sun, J.-B.; Zeng, B.; Shi, X.-J.; Zhou, Y.; Niu, Y.; Nie, S.-Q.; Feng, F.; Liang, Y.; Wu, F.-H. Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities. Molecules 2015, 20, 14879-14888.
Zhang B-B, He B-Q, Sun J-B, Zeng B, Shi X-J, Zhou Y, Niu Y, Nie S-Q, Feng F, Liang Y, Wu F-H. Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities. Molecules. 2015; 20(8):14879-14888.Chicago/Turabian Style
Zhang, Bao-Bao; He, Bai-Qiu; Sun, Jian-Bo; Zeng, Biao; Shi, Xiao-Ji; Zhou, Yong; Niu, Ying; Nie, Shi-Qi; Feng, Feng; Liang, Yan; Wu, Fei-Hua. 2015. "Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities." Molecules 20, no. 8: 14879-14888.