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Molecules 2015, 20(8), 14611-14620; doi:10.3390/molecules200814611

New Bergamotane Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasiliense

1
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China
2
State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China
3
University of Chinese Academy of Sciences, Beijing 100049, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 7 July 2015 / Revised: 29 July 2015 / Accepted: 30 July 2015 / Published: 12 August 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [750 KB, uploaded 12 August 2015]   |  

Abstract

Brasilamides K-N (14), four new bergamotane sesquiterpenoids; with 4-oxatricyclo (3.3.1.0 2,7)nonane (1)and 9-oxatricyclo(4.3.0.0 4,7)nonane (24) skeletons; were isolated from the scale-up fermentation cultures of the plant endophytic fungus Paraconiothynium brasiliense Verkley. The previously identified sesquiterpenoids brasilamides A and C (5 and 6) were also reisolated in the current work. The structures of 14 were elucidated primarily by interpretation of NMR spectroscopic data. The absolute configurations of 13 were deduced by analogy to the co-isolated metabolites 5 and 6; whereas that of C-12 in 4 was assigned using the modified Mosher method. The cytotoxicity of all compounds against a panel of eight human tumor cell lines were assayed. View Full-Text
Keywords: Paraconiothynium brasiliense; endophytic fungus; sesquiterpenoid Paraconiothynium brasiliense; endophytic fungus; sesquiterpenoid
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Guo, Z.; Ren, F.; Che, Y.; Liu, G.; Liu, L. New Bergamotane Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasiliense. Molecules 2015, 20, 14611-14620.

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