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Molecules 2015, 20(8), 14565-14575; doi:10.3390/molecules200814565

Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza)

1
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China
2
Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China
3
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
4
Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 3 July 2015 / Revised: 28 July 2015 / Accepted: 31 July 2015 / Published: 12 August 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [746 KB, uploaded 12 August 2015]   |  

Abstract

Four new cyclohexylideneacetonitrile derivatives 14, named menisdaurins B–E, as well as three known cyclohexylideneacetonitrile derivatives—menisdaurin (5), coclauril (6), and menisdaurilide (7)—were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 17 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL. View Full-Text
Keywords: antiviral; Bruguiera gymnorrhiza; cyclohexylideneacetonitrile derivative antiviral; Bruguiera gymnorrhiza; cyclohexylideneacetonitrile derivative
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MDPI and ACS Style

Yi, X.-X.; Deng, J.-G.; Gao, C.-H.; Hou, X.-T.; Li, F.; Wang, Z.-P.; Hao, E.-W.; Xie, Y.; Du, Z.-C.; Huang, H.-X.; Huang, R.-M. Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza). Molecules 2015, 20, 14565-14575.

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