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Molecules 2015, 20(8), 14022-14032; doi:10.3390/molecules200814022

Palladium-Catalyzed One-Pot Approach to 3-(Diarylmethylene)oxindoles from Propiolamidoaryl Triflate

Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Roman Dembinski
Received: 7 July 2015 / Revised: 29 July 2015 / Accepted: 31 July 2015 / Published: 3 August 2015
(This article belongs to the Section Organic Synthesis)
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Abstract

3-(Diarylmethylene)oxindoles have been synthesized from propiolamidoaryl triflate utilizing a palladium-catalyzed one-pot reaction consisting of three successive reactions: Sonogashira, Heck, and Suzuki-Miyaura. This method allows for the production of a complex skeleton of 3-(diarylmethylene)oxindole from propiolamidoaryl triflate using a commercially available aryl iodide and arylboronic acid in a simple and efficient way with moderate yield and stereoselectivity. View Full-Text
Keywords: 3-(Diarylmethylene)oxindole; one-pot reaction; aryl triflate; palladium-catalyzed reaction 3-(Diarylmethylene)oxindole; one-pot reaction; aryl triflate; palladium-catalyzed reaction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, D.; Park, S.; Yu, Y.; Shin, K.J.; Seo, J.H. Palladium-Catalyzed One-Pot Approach to 3-(Diarylmethylene)oxindoles from Propiolamidoaryl Triflate. Molecules 2015, 20, 14022-14032.

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