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Molecules 2015, 20(4), 5825-5834; doi:10.3390/molecules20045825

Three New Pigment Protein Tyrosine Phosphatases Inhibitors from the Insect Parasite Fungus Cordyceps gracilioides: Terreusinone A, Pinophilin C and Cryptosporioptide A

1
College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, China
2
Biotechnology Center of Hebei Province, Hebei University, Baoding 071002, China
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 29 January 2015 / Revised: 25 March 2015 / Accepted: 25 March 2015 / Published: 2 April 2015
(This article belongs to the Section Organic Synthesis)
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Abstract

Three new pigment compounds—terreusinone A (1), pinophilin C (2) and cryptosporioptide A (3)—were isolated from a solid culture of Cordyceps gracilioides. The structures of these compounds were determined by extensive spectroscopic analysis including HRESIMS, 1D- and 2D-NMR. The structure of terreusinone A (1) was further confirmed by single-crystal X-ray crystallographic diffraction analysis. In an in vitro activity assay, 1, 2 and 3 exhibited high inhibitory activity against PTP1B, SHP2, CDC25B, LAR and SHP1. Terreusinone A (1) inhibited PTP1B, SHP2, CDC25B, LAR and SHP1 enzyme with IC50 values 12.5, >50, 4.1, 10.6, 5.6 µg/mL, respectively; pinophilin C (2) with IC50 values 6.8, 8.0, 4.5, 4.7, 3.4 µg/mL, respectively; and cryptosporioptide A (3) with IC50 values 7.3, 5.7, 7.6, >50, 4.9 µg/mL, respectively. View Full-Text
Keywords: protein tyrosine phosphatases inhibitors; Cordyceps gracilioides; terreusinone A; pinophilin C; cryptosporioptide A protein tyrosine phosphatases inhibitors; Cordyceps gracilioides; terreusinone A; pinophilin C; cryptosporioptide A
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wei, P.-Y.; Liu, L.-X.; Liu, T.; Chen, C.; Luo, D.-Q.; Shi, B.-Z. Three New Pigment Protein Tyrosine Phosphatases Inhibitors from the Insect Parasite Fungus Cordyceps gracilioides: Terreusinone A, Pinophilin C and Cryptosporioptide A. Molecules 2015, 20, 5825-5834.

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