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Molecules 2015, 20(4), 5625-5637; doi:10.3390/molecules20045625

Design, Synthesis, and Insecticidal Activity of Some Novel Diacylhydrazine and Acylhydrazone Derivatives

College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 26 February 2015 / Revised: 22 March 2015 / Accepted: 25 March 2015 / Published: 30 March 2015
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [732 KB, uploaded 30 March 2015]   |  


In this study a series of diacylhydrazine and acylhydrazone derivatives were designed and synthesized according to the method of active group combination and the principles of aromatic group bioisosterism. The structures of the novel derivatives were determined on the basis on 1H-NMR, IR and ESI-MS spectral data. All of the compounds were evaluated for their in vivo insecticidal activity against the third instar larvae of Spodoptera exigua Hiibner, Helicoverpa armigera Hubner, Plutella xyllostella Linnaeus and Pieris rapae Linne, respectively, at a concentration of 10 mg/L. The results showed that all of the derivatives displayed high insecticidal activity. Most of the compounds presented higher insecticidal activity against S. exigua than the reference compounds tebufenozide, metaflumizone and tolfenpyrad, and approximately identical insecticidal activity against H. armigera, P. xyllostella and P. rapae as the references metaflumizone and tolfenpyrad. View Full-Text
Keywords: diacylhydrazine; acylhydrazone; aromatic diamide; insecticidal activity; synthesis diacylhydrazine; acylhydrazone; aromatic diamide; insecticidal activity; synthesis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sun, J.; Zhou, Y. Design, Synthesis, and Insecticidal Activity of Some Novel Diacylhydrazine and Acylhydrazone Derivatives. Molecules 2015, 20, 5625-5637.

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