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Molecules 2015, 20(3), 4383-4394; doi:10.3390/molecules20034383

Synthesis and Antifungal Activity of the Derivatives of Novel Pyrazole Carboxamide and Isoxazolol Pyrazole Carboxylate

College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 13 January 2015 / Revised: 17 February 2015 / Accepted: 4 March 2015 / Published: 9 March 2015
(This article belongs to the Section Organic Synthesis)
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Abstract

A series of pyrazole carboxamide and isoxazolol pyrazole carboxylate derivatives were designed and synthesized in this study. The structures of the compounds were elucidated based on spectral data (infrared, proton nuclear magnetic resonance and mass spectroscopy). Then, all of the compounds were bioassayed in vitro against four types of phytopathogenic fungi (Alternaria porri, Marssonina coronaria, Cercospora petroselini and Rhizoctonia solani) using the mycelium growth inhibition method. The results showed that some of the synthesized pyrazole carboxamides displayed notable antifungal activity. The isoxazole pyrazole carboxylate 7ai exhibited significant antifungal activity against R. solani, with an EC50 value of 0.37 μg/mL. Nonetheless, this value was lower than that of the commercial fungicide, carbendazol. View Full-Text
Keywords: pyrazole carboxamide; isoxazolol pyrazole carboxylate; antifungal activity; synthesis; fungi pyrazole carboxamide; isoxazolol pyrazole carboxylate; antifungal activity; synthesis; fungi
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sun, J.; Zhou, Y. Synthesis and Antifungal Activity of the Derivatives of Novel Pyrazole Carboxamide and Isoxazolol Pyrazole Carboxylate. Molecules 2015, 20, 4383-4394.

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