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Molecules 2015, 20(12), 22881-22889; doi:10.3390/molecules201219888

The Sensitivity of Endodontic Enterococcus spp. Strains to Geranium Essential Oil

1
Department of Microbiology and Medical Laboratory Immunology, Medical University of Lodz, 92-231 Lodz, Pomorska 251, Poland
2
Department of Environmental Biology, Medical University of Lodz, 90-752 Lodz, Żeligowskiego 7/9, Poland
3
Department of General Dentistry, Medical University of Lodz, 92-231 Lodz, Pomorska 251, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 18 September 2015 / Revised: 7 December 2015 / Accepted: 14 December 2015 / Published: 21 December 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [199 KB, uploaded 21 December 2015]

Abstract

Enterococci are able to survive endodontic procedures and contribute to the failure of endodontic therapy. Thus, it is essential to identify novel ways of eradicating them from infected root canals. One such approach may be the use of antimicrobials such as plant essential oils. Enterococcal strains were isolated from endodontically treated teeth by standard microbiological methods. Susceptibility to antibiotics was evaluated by the disc-diffusion method. The minimal inhibitory concentration (MIC) of geranium essential oil was investigated by microdilution in 96-well microplates in Mueller Hinton Broth II. Biofilm eradication concentrations were checked in dentin tests. Geranium essential oil inhibited enterococcal strains at concentrations ranging from 1.8–4.5 mg/mL. No correlation was shown between resistance to antibiotics and the MICs of the test antimicrobials. The MICs of the test oil were lower than those found to show cytotoxic effects on the HMEC-1 cell line. Geranium essential oil eradicated enterococcal biofilm at concentrations of 150 mg/mL. Geranium essential oil inhibits the growth of endodontic enterococcal species at lower concentrations than those required to reach IC50 against the HMEC-1 cell line, and is effective against bacteria protected in biofilm at higher concentrations. In addition, bacteria do not develop resistance to essential oils. Hence, geranium essential oil represents a possible alternative to other antimicrobials during endodontic procedures. View Full-Text
Keywords: enterococci; endodontic treatment; geranium essential oil enterococci; endodontic treatment; geranium essential oil
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Łysakowska, M.E.; Sienkiewicz, M.; Banaszek, K.; Sokołowski, J. The Sensitivity of Endodontic Enterococcus spp. Strains to Geranium Essential Oil. Molecules 2015, 20, 22881-22889.

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