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Molecules 2015, 20(12), 22301-22314; doi:10.3390/molecules201219847

Potent PPARγ Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells

1
Experimental Therapeutics Center, Institute of Pharmaceuticals and Nutraceuticals Malaysia, Blok 5-A, Halaman Bukit Gambir, Penang 11700, Malaysia
2
Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
3
Biomedical Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 46150, Selangor Darul Ehsan, Malaysia
4
School of Biological Sciences, Universiti Sains Malaysia, Penang 11800 USM, Malaysia
5
Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Terengganu 21030, Terengganu, Malaysia
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 22 October 2015 / Revised: 27 November 2015 / Accepted: 1 December 2015 / Published: 12 December 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [3982 KB, uploaded 12 December 2015]   |  

Abstract

Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a modified ELISA binding assay and showed to possess PPARγ ligand activity. They were corresponded to PPARγ-mediated cellular response, stimulated adipocyte differentiation but produced lower amount of fat droplets compared to a conventional anti-diabetic agent, rosiglitazone. The up-regulation of adipocytes was followed by increased adipocyte-related gene expressions such as adiponectin, adipsin, and PPARγ. The S. macrophylla compounds also promoted cellular glucose uptake via the translocation of GLUT4 glucose transporter. View Full-Text
Keywords: Swietenia macrophylla; PPARγ ligand; GLUT4 translocation; glucose uptake Swietenia macrophylla; PPARγ ligand; GLUT4 translocation; glucose uptake
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lau, W.K.; Goh, B.H.; Kadir, H.A.; Shu-Chien, A.C.; Tengku Muhammad, T.S. Potent PPARγ Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells. Molecules 2015, 20, 22301-22314.

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