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Molecules 2015, 20(12), 21870-21880; doi:10.3390/molecules201219811

Design, Synthesis and Bioactivities of Novel Dichloro-Allyloxy-Phenol-Containing Pyrazole Oxime Derivatives

College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China
Nantong Nanshen Plant Protection Science and Technology Development Co. Ltd., Nantong 226017, China
School of Chemical and Biological Engineering, Nantong Vocational University, Nantong 226007, China
Authors to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 10 November 2015 / Revised: 27 November 2015 / Accepted: 2 December 2015 / Published: 8 December 2015
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [556 KB, uploaded 8 December 2015]   |  


In this study, in order to find novel biologically active pyrazole oxime compounds, a number of dichloro-allyloxy-phenol-containing pyrazole oximes were designed and synthesized according to the method of active group combination. All of the target compounds were confirmed by 1H-NMR, 13C-NMR and elemental analysis. In addition, bioassays showed that all of the newly synthesized compounds had no acaricidal activity against Tetranychus cinnabarinus and low insecticidal activity against Aphis craccivora at tested concentrations. However, most of them displayed excellent insecticidal activity against Oriental armyworm at a concentration of 500 μg/mL, and some designed compounds still exhibited potent insecticidal activity against Oriental armyworm even at the dose of 20 μg/mL, especially compounds 7f, 7n and 7p had 100%, 90% and 90% inhibition rates, respectively, which were comparable to that of the control pyridalyl. View Full-Text
Keywords: pyrazole oxime; dichloro-allyoxy-phenol; synthesis; biological activity pyrazole oxime; dichloro-allyoxy-phenol; synthesis; biological activity

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dai, H.; Ye, L.; Zhuang, H.; Dai, B.; Fang, Y.; Shi, Y. Design, Synthesis and Bioactivities of Novel Dichloro-Allyloxy-Phenol-Containing Pyrazole Oxime Derivatives. Molecules 2015, 20, 21870-21880.

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