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Molecules 2015, 20(12), 20979-20997; doi:10.3390/molecules201219739

DNA Aptamers in the Diagnosis and Treatment of Human Diseases

1,†
,
2,†
and
1,*
1
Faculty of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
2
Department of Genomic Epidemiology, Research Center for Environment and Developmental Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Alain O.A. Miller and Jean Jacques Vanden Eynde
Received: 15 September 2015 / Revised: 16 November 2015 / Accepted: 16 November 2015 / Published: 25 November 2015
(This article belongs to the Special Issue Aptamers: Past, Present, and Future)
View Full-Text   |   Download PDF [787 KB, uploaded 25 November 2015]   |  

Abstract

Aptamers have a promising role in the field of life science and have been extensively researched for application as analytical tools, therapeutic agents and as vehicles for targeted drug delivery. Compared with RNA aptamers, DNA aptamers have inherent advantages in stability and facility of generation and synthesis. To better understand the specific potential of DNA aptamers, an overview of the progress in the generation and application of DNA aptamers in human disease diagnosis and therapy are presented in this review. Special attention is given to researches that are relatively close to practical application. DNA aptamers are expected to have great potential in the diagnosis and treatment of human diseases. View Full-Text
Keywords: DNA aptamers; human diseases; diagnosis; therapeutics DNA aptamers; human diseases; diagnosis; therapeutics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhu, Q.; Liu, G.; Kai, M. DNA Aptamers in the Diagnosis and Treatment of Human Diseases. Molecules 2015, 20, 20979-20997.

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