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Molecules 2015, 20(12), 21364-21372; doi:10.3390/molecules201219776

A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats

School of Traditional Chinese Materia Medica, Tianjin University of TCM, 312 Anshan West Road, Nankai District, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, No. 88, Yuquan Road, Nankai District, Tianjin 300193, China
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 7 October 2015 / Revised: 18 November 2015 / Accepted: 19 November 2015 / Published: 1 December 2015
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [747 KB, uploaded 1 December 2015]   |  


Simiaowan (SMW) is a famous Chinese prescription widely used in clinical treatment of rheumatoid arthritis (RA). The aim of the present study is to determine novel biomarkers to increase the current understanding of RA mechanisms, as well as the underlying therapeutic mechanism of SMW, in RA-model rats. Plasma extracts from control, RA model, and SMW-treated rats were analyzed by gas chromatography coupled with mass spectrometry (GC-MS). An orthogonal partial least-square discriminant analysis (OPLS-DA) model was created to detect metabolites that were expressed in significantly different amounts between the RA model and the control rats and investigate the therapeutic effect of SMW. Metabonomics may prove to be a valuable tool for determining the efficacy of complex traditional prescriptions. View Full-Text
Keywords: GC-MS; metabonomics; rheumatoid arthritis; Simiaowan GC-MS; metabonomics; rheumatoid arthritis; Simiaowan

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, Y.; Guo, X.; Xie, J.; Hou, Z.; Li, Y. A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats. Molecules 2015, 20, 21364-21372.

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