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Molecules 1997, 2(11), 176-179; doi:10.3390/21100176
Article
Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles
Received: 24 October 1997 / Accepted: 7 November 1997 / Published: 15 November 1997
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Abstract: Phosphorus pentoxide is commonly used for the dehydration of heterocyclic carboxamides to the corresponding nitriles. In this report, the use of cyanuric chloride/N,N-disubstituted formamide for this reaction is described. The advantages of this procedure are mild reaction conditions and good yields. Depending on the reaction conditions and the structures of the amides, the nitriles are obtained in yields from 51% to 99%. Several of the oxazole carbonitriles synthesized by this procedure have not yet been described.
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MDPI and ACS Style
Aquino, F.; Karge, R.; Pauling, H.; Bonrath, W. Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles. Molecules 1997, 2, 176-179.
AMA StyleAquino F, Karge R, Pauling H, Bonrath W. Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles. Molecules. 1997; 2(11):176-179.
Chicago/Turabian StyleAquino, Fabrice; Karge, Reinhard; Pauling, Horst; Bonrath, Werner. 1997. "Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles." Molecules 2, no. 11: 176-179.
Molecules
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