Molecules 1997, 2(11), 176-179; doi:10.3390/21100176
Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles
Vitamin Research and Technology Development, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland
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Received: 24 October 1997 / Accepted: 7 November 1997 / Published: 15 November 1997
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Abstract
Phosphorus pentoxide is commonly used for the dehydration of heterocyclic carboxamides to the corresponding nitriles. In this report, the use of cyanuric chloride/N,N-disubstituted formamide for this reaction is described. The advantages of this procedure are mild reaction conditions and good yields. Depending on the reaction conditions and the structures of the amides, the nitriles are obtained in yields from 51% to 99%. Several of the oxazole carbonitriles synthesized by this procedure have not yet been described.
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MDPI and ACS Style
Aquino, F.; Karge, R.; Pauling, H.; Bonrath, W. Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles. Molecules 1997, 2, 176-179.
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