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Molecules 1997, 2(11), 176-179; doi:10.3390/21100176

Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles

Vitamin Research and Technology Development, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland
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Received: 24 October 1997 / Accepted: 7 November 1997 / Published: 15 November 1997
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Abstract

Phosphorus pentoxide is commonly used for the dehydration of heterocyclic carboxamides to the corresponding nitriles. In this report, the use of cyanuric chloride/N,N-disubstituted formamide for this reaction is described. The advantages of this procedure are mild reaction conditions and good yields. Depending on the reaction conditions and the structures of the amides, the nitriles are obtained in yields from 51% to 99%. Several of the oxazole carbonitriles synthesized by this procedure have not yet been described.
Keywords: Dehydration; heterocyclic carboxamides; heterocyclic carbonitriles; cyanuric chloride/DMF Dehydration; heterocyclic carboxamides; heterocyclic carbonitriles; cyanuric chloride/DMF
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Aquino, F.; Karge, R.; Pauling, H.; Bonrath, W. Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles. Molecules 1997, 2, 176-179.

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