Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles

doi:10.3390/21100176

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Molecules 1997, 2(11), 176-179; doi:10.3390/21100176

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Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles

Fabrice Aquino, Reinhard Karge, Horst Pauling and Werner Bonrath *

Vitamin Research and Technology Development, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland

* Author to whom correspondence should be addressed.

Received: 24 October 1997; Accepted: 7 November 1997 / Published: 15 November 1997

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Abstract: Phosphorus pentoxide is commonly used for the dehydration of heterocyclic carboxamides to the corresponding nitriles. In this report, the use of cyanuric chloride/N,N-disubstituted formamide for this reaction is described. The advantages of this procedure are mild reaction conditions and good yields. Depending on the reaction conditions and the structures of the amides, the nitriles are obtained in yields from 51% to 99%. Several of the oxazole carbonitriles synthesized by this procedure have not yet been described.

Keywords: Dehydration; heterocyclic carboxamides; heterocyclic carbonitriles; cyanuric chloride/DMF

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MDPI and ACS Style

Aquino, F.; Karge, R.; Pauling, H.; Bonrath, W. Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles. Molecules 1997, 2, 176-179.

AMA Style

Aquino F, Karge R, Pauling H, Bonrath W. Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles. Molecules. 1997; 2(11):176-179.

Chicago/Turabian Style

Aquino, Fabrice; Karge, Reinhard; Pauling, Horst; Bonrath, Werner. 1997. "Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles." Molecules 2, no. 11: 176-179.

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