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Molecules 1997, 2(11), 176-179; doi:10.3390/21100176
Article

Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles

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Received: 24 October 1997; Accepted: 7 November 1997 / Published: 15 November 1997
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Abstract: Phosphorus pentoxide is commonly used for the dehydration of heterocyclic carboxamides to the corresponding nitriles. In this report, the use of cyanuric chloride/N,N-disubstituted formamide for this reaction is described. The advantages of this procedure are mild reaction conditions and good yields. Depending on the reaction conditions and the structures of the amides, the nitriles are obtained in yields from 51% to 99%. Several of the oxazole carbonitriles synthesized by this procedure have not yet been described.
Keywords: Dehydration; heterocyclic carboxamides; heterocyclic carbonitriles; cyanuric chloride/DMF Dehydration; heterocyclic carboxamides; heterocyclic carbonitriles; cyanuric chloride/DMF
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Aquino, F.; Karge, R.; Pauling, H.; Bonrath, W. Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles. Molecules 1997, 2, 176-179.

AMA Style

Aquino F, Karge R, Pauling H, Bonrath W. Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles. Molecules. 1997; 2(11):176-179.

Chicago/Turabian Style

Aquino, Fabrice; Karge, Reinhard; Pauling, Horst; Bonrath, Werner. 1997. "Dehydration of Aromatic Heterocyclic Carboxamides to Aromatic Heterocyclic Carbonitriles." Molecules 2, no. 11: 176-179.


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