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Molecules 2014, 19(7), 9689-9711; doi:10.3390/molecules19079689

Ionic Liquid-Based Vacuum Microwave-Assisted Extraction Followed by Macroporous Resin Enrichment for the Separation of the Three Glycosides Salicin, Hyperin and Rutin from Populus Bark

1
Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China
2
Sichuan Academy of Forestry, Chengdu 610081, China
*
Authors to whom correspondence should be addressed.
Received: 16 May 2014 / Revised: 23 June 2014 / Accepted: 1 July 2014 / Published: 7 July 2014
(This article belongs to the Section Natural Products)
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Abstract

An effective ionic liquid vacuum microwave-assisted method was developed for extraction of the thermo- and oxygen-sensitive glycosides salicin, hyperin and rutin from Populus bark due to the strong solvating effects of ionic liquids on plant cell walls. In this study, [C4mim]BF4 solution was selected as the extracting solution for extraction of the target analytes. After optimization by single factor experiments and response surface methodology, the optimum condition parameters were achieved, which included 1.0 M [C4mim]BF4, 2 h soaking time, −0.08 MPa vacuum, 20 min microwave irradiation time, 400 W microwave irradiation power and 25 mL/g liquid/solid ratio. Under the optimum conditions, higher extraction yields of salicin (35.53 mg/g), hyperin (1.32 mg/g) and rutin (2.40 mg/g) were obtained. Compared with other extraction methods, the developed method provided higher yields of the three target components after a relatively shorter extraction time (20 min). No obvious degradation of the target analytes was observed under the optimum conditions in performed stability studies and the proposed method had a high reproducibility. Meanwhile, after adsorption and desorption on macroporous D101 resin, the target analytes can be effectively separated from the [C4mim]BF4 ionic liquid extraction solution and the yields of salicin, hyperin and rutin were 89%, 82% and 84%, respectively. The recovered [C4mim]BF4 ionic liquid presented a good extraction effect on the three analytes after recycling five times. View Full-Text
Keywords: ionic liquid vacuum microwave-assisted extraction (ILVMAE); Populus bark; macroporous resin; glycoside ionic liquid vacuum microwave-assisted extraction (ILVMAE); Populus bark; macroporous resin; glycoside
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Chen, F.; Mo, K.; Liu, Z.; Yang, F.; Hou, K.; Li, S.; Zu, Y.; Yang, L. Ionic Liquid-Based Vacuum Microwave-Assisted Extraction Followed by Macroporous Resin Enrichment for the Separation of the Three Glycosides Salicin, Hyperin and Rutin from Populus Bark. Molecules 2014, 19, 9689-9711.

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