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Molecules 2014, 19(6), 7610-7620; doi:10.3390/molecules19067610

An Efficient Synthesis of Pyridoxal Oxime Derivatives under Microwave Irradiation

Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology Osijek, Kuhačeva 20, 31000 Osijek, Croatia
University of Zagreb, Faculty of Textile Technology, Department of Applied Chemistry, Prilaz baruna Filipovića 28a, 10000 Zagreb, Croatia
Faculty of Food Technology and Biotechnology, Department of Chemistry and Biochemistry, Pierottijeva 6, 10000 Zagreb, Croatia
Authors to whom correspondence should be addressed.
Received: 7 May 2014 / Revised: 28 May 2014 / Accepted: 3 June 2014 / Published: 6 June 2014
(This article belongs to the Section Organic Synthesis)
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Quaternary salts of pyridoxal oxime have been synthesized by the quaternization of pyridoxal oxime with substituted phenacyl bromides using microwave heating. Microwave-assisted rapid synthesis was done both in solvent (acetone) and under solvent-free conditions. Good to excellent yields (58%–94%) were obtained in acetone in very short reaction times (3–5 min) as well as in the solvent-free procedure (42%–78%) in very short reaction times (7–10 min) too. Effective metodologies for the preparation of pyridoxal oxime quaternary salts, having the advantagies of being eco-friendly, easy to handle, and performed in shorter reactions time are presented. The structure of compound 7, in which a 4-fluorophenacyl moiety is bonded to the pyridinium ring nitrogen atom, was unequivocally confirmed by the single-crystal X-ray diffraction method. View Full-Text
Keywords: eco-friendly quaternization; microwave synthesis; phenacyl bromides; pyridoxal oxime eco-friendly quaternization; microwave synthesis; phenacyl bromides; pyridoxal oxime

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Gašo-Sokač, D.; Bušić, V.; Cetina, M.; Jukić, M. An Efficient Synthesis of Pyridoxal Oxime Derivatives under Microwave Irradiation. Molecules 2014, 19, 7610-7620.

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