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Molecules 2014, 19(6), 7429-7439; doi:10.3390/molecules19067429

Easy Access to Evans’ Oxazolidinones. Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative

1
Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte–MG 31270-901, Brazil
2
Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa–MG 36570-000, Brazil
*
Author to whom correspondence should be addressed.
Received: 26 March 2014 / Revised: 28 May 2014 / Accepted: 28 May 2014 / Published: 6 June 2014
(This article belongs to the Section Organic Synthesis)
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Abstract

An interesting new approach was developed for the synthesis of Evans’ chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct. The antibacterial activity of this oxazolidinone was tested against Staphylococcus aureus strains isolated from animals with mastitis infections. View Full-Text
Keywords: Evans’ oxazolidinones; stereoselective synthesis; Morita-Baylis-Hillman adduct; Staphylococcus aureus; mastitis bovina Evans’ oxazolidinones; stereoselective synthesis; Morita-Baylis-Hillman adduct; Staphylococcus aureus; mastitis bovina
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Diaz, G.; de Freitas, M.A.A.; Ricci-Silva, M.E.; Diaz, M.A.N. Easy Access to Evans’ Oxazolidinones. Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative. Molecules 2014, 19, 7429-7439.

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