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Molecules 2014, 19(5), 5898-5912; doi:10.3390/molecules19055898
Article

Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative

1, 2, 1, 3, 3, 3, 3 and 1,*
Received: 7 February 2014; in revised form: 26 April 2014 / Accepted: 28 April 2014 / Published: 7 May 2014
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Abstract: A resorcinarene derivative of vanillin, resvan, was synthesized and characterized by spectroscopic techniques. We measured the cytotoxicity (in vivo and in vitro), antioxidant and anti-Toxoplasma activities of vanillin and the resorcinarene compound. Here we show that vanillin has a dose-dependent behavior with IC50 of 645 µg/mL through an in vitro cytotoxicity assay. However, we could not observe any cytotoxic response at higher concentrations of resvan (IC50 > 2,000 µg/mL). The in vivo acute toxicity assays of vanillin and resvan exhibited a significant safety margin indicated by a lack of systemic and behavioral toxicity up to 300 mg/kg during the first 30 min, 24 h or 14 days after administration. The obtained derivative showed greater antioxidative activity (84.9%) when comparing to vanillin (19.4%) at 1,000 μg/mL. In addition, vanillin presents anti-Toxoplasma activity, while resvan does not show that feature. Our findings suggest that this particular derivative has an efficient antioxidant activity and a negligible cytotoxic effect, making it a potential target for further biological investigations.
Keywords: vanillin; resorcinarene; antioxidant; anti-Toxoplasma vanillin; resorcinarene; antioxidant; anti-Toxoplasma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Oliveira, C.B.S.; Meurer, Y.S.R.; Oliveira, M.G.; Medeiros, W.M.T.Q.; Silva, F.O.N.; Brito, A.C.F.; Pontes, D.L.; Andrade-Neto, V.F. Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative. Molecules 2014, 19, 5898-5912.

AMA Style

Oliveira CBS, Meurer YSR, Oliveira MG, Medeiros WMTQ, Silva FON, Brito ACF, Pontes DL, Andrade-Neto VF. Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative. Molecules. 2014; 19(5):5898-5912.

Chicago/Turabian Style

Oliveira, Claudio B.S.; Meurer, Ywlliane S.R.; Oliveira, Marianne G.; Medeiros, Wendy M.T.Q.; Silva, Francisco O.N.; Brito, Ana C.F.; Pontes, Daniel L.; Andrade-Neto, Valter F. 2014. "Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative." Molecules 19, no. 5: 5898-5912.


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