Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative
AbstractA resorcinarene derivative of vanillin, resvan, was synthesized and characterized by spectroscopic techniques. We measured the cytotoxicity (in vivo and in vitro), antioxidant and anti-Toxoplasma activities of vanillin and the resorcinarene compound. Here we show that vanillin has a dose-dependent behavior with IC50 of 645 µg/mL through an in vitro cytotoxicity assay. However, we could not observe any cytotoxic response at higher concentrations of resvan (IC50 > 2,000 µg/mL). The in vivo acute toxicity assays of vanillin and resvan exhibited a significant safety margin indicated by a lack of systemic and behavioral toxicity up to 300 mg/kg during the first 30 min, 24 h or 14 days after administration. The obtained derivative showed greater antioxidative activity (84.9%) when comparing to vanillin (19.4%) at 1,000 μg/mL. In addition, vanillin presents anti-Toxoplasma activity, while resvan does not show that feature. Our findings suggest that this particular derivative has an efficient antioxidant activity and a negligible cytotoxic effect, making it a potential target for further biological investigations.
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Oliveira, C.B.S.; Meurer, Y.S.R.; Oliveira, M.G.; Medeiros, W.M.T.Q.; Silva, F.O.N.; Brito, A.C.F.; Pontes, D.L.; Andrade-Neto, V.F. Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative. Molecules 2014, 19, 5898-5912.
Oliveira CBS, Meurer YSR, Oliveira MG, Medeiros WMTQ, Silva FON, Brito ACF, Pontes DL, Andrade-Neto VF. Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative. Molecules. 2014; 19(5):5898-5912.Chicago/Turabian Style
Oliveira, Claudio B.S.; Meurer, Ywlliane S.R.; Oliveira, Marianne G.; Medeiros, Wendy M.T.Q.; Silva, Francisco O.N.; Brito, Ana C.F.; Pontes, Daniel L.; Andrade-Neto, Valter F. 2014. "Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative." Molecules 19, no. 5: 5898-5912.