Molecules 2014, 19(4), 4479-4490; doi:10.3390/molecules19044479
Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
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Received: 28 January 2014 / Revised: 30 March 2014 / Accepted: 3 April 2014 / Published: 10 April 2014
(This article belongs to the Section Natural Products)
Abstract
One new flavonoid named (2R,3R)-7-O-galloylplumbocatechin A (1) and three known flavonoids, (−)-5,3',4',5'-tetrahydroxyflavan-7-gallate (2), (+)-3,5,3',4',5'-penta-hydroxyflavan-7-gallate (3), and (−)-7,4'-di-O-galloyltricetiflavan (4), were isolated from Pithecellobium clypearia Benth. Their structures were elucidated based on spectroscopic analysis, including homonuclear and heteronuclear correlation NMR (HSQC and HMBC) experiments. In vitro assays, compounds 1 and 2 showed moderate inhibitory effects against influenza H1N1 virus neuraminidase (NA). Compounds 1–4 were all found to inhibit the expression of proinflammatory cytokines IL-6 or MCP-1 induced by influenza H1N1 virus in human A549 lung carcinoma cells. View Full-TextKeywords:
(2R,3R)-7-O-galloylplumbocatechin A; Pithecellobium clypearia Benth; neuraminidase (NA) of influenza virus; anti-inflammatory activity
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Kang, J.; Liu, C.; Wang, H.; Li, B.; Li, C.; Chen, R.; Liu, A. Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth. Molecules 2014, 19, 4479-4490.
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