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Molecules 2014, 19(2), 2100-2113; doi:10.3390/molecules19022100

Comparative Evaluation of the Radical-Scavenging Activities of Fucoxanthin and Its Stereoisomers

2,*  and 1,*
1 Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China 2 State Oceanic Administration Third Institute of Oceanography, Xiamen 361005, Fujian, China
* Authors to whom correspondence should be addressed.
Received: 6 November 2013 / Revised: 7 January 2014 / Accepted: 8 February 2014 / Published: 17 February 2014
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Fucoxanthin (Fuco) is a characteristic carotenoid of brown seaweeds. In the present study, Fuco and its stereoisomers 9'Z-Fuco, 13Z- and 13'Z-Fuco were extracted from Laminaria japonica Aresch. They were isolated and purified by silica gel column chromatography, Sephadex LH-20, and reversed-phase HPLC. The radical-scavenging activities of the three stereoisomers were evaluated toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, 2-2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical, hydroxyl radical, and superoxide radical. The order of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity was 13Z- and 13'Z-Fuco > (all-E)-Fuco > 9'Z-Fuco. The order of 2-2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and hydroxyl radical-scavenging activities were 9'Z-Fuco > (all-E)-Fuco > 13Z-and 13'Z-Fuco. The order of superoxide radical-scavenging activity was 13Z- and 13'Z-Fuco > (all-E)-Fuco > 9'Z-Fuco. The scavenging activities of Fuco and its stereoisomers toward the four radical types were all dose-dependent. The ABTS, DPPH, and superoxide radical-scavenging activities were all weaker than that of tocopherol (VE), while their hydroxyl radical-scavenging activities were stronger than that of VE. The results confirmed that Fuco and its stereoisomers have potent antioxidant activities.
Keywords: fucoxanthin; stereoisomers; radical-scavenging activities fucoxanthin; stereoisomers; radical-scavenging activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, Y.; Fang, H.; Xie, Q.; Sun, J.; Liu, R.; Hong, Z.; Yi, R.; Wu, H. Comparative Evaluation of the Radical-Scavenging Activities of Fucoxanthin and Its Stereoisomers. Molecules 2014, 19, 2100-2113.

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