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Molecules 2014, 19(2), 2029-2041; doi:10.3390/molecules19022029
Article

Effects of Danshensu and Salvianolic Acid B from Salvia miltiorrhiza Bunge (Lamiaceae) on Cell Proliferation and Collagen and Melanin Production

1
, 2
, 3,4
, 5,*  and 1,*
1 Department of Cosmetic Science, Providence University, 200 Chung-Chi Road, Shalu, Taichung 43301, Taiwan 2 Department of Cosmetic Science and Management, Mackay Medicine, Nursing and Management College, 92 Shengjing Road, Beitou, Taipei 11260, Taiwan 3 Department of Medical Research, China Medical University Hospital, 2 Yuh-Der Road, Taichung 40447, Taiwan 4 School of Chinese Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan 5 Department of Food and Beverage Management, Taiwan Hospitality and Tourism College, 268 Chong-Hsing St., Feng-Shan Village, Shou-Feng County, Hualien 974, Taiwan
* Authors to whom correspondence should be addressed.
Received: 4 December 2013 / Revised: 1 February 2014 / Accepted: 8 February 2014 / Published: 13 February 2014
(This article belongs to the Section Metabolites)
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Abstract

Danshensu (DSU) and salvianolic acid B (SAB) are the primary water-soluble compounds of Salvia miltiorrhiza Bunge (Lamiaceae). In this study, we analyzed the effects of DSU, SAB and a S. miltiorrhiza extract (SME) on cell proliferation. Additionally, the effects of DSU and SAB on collagen synthesis in Detroit 551 human normal fibroblast cells and on melanin production in B16 melanoma cells were verified. The results demonstrated that SME can enhance the proliferation of Detroit 551 cells and that this boost may be caused by DSU and SAB. This research showed that SME, DSU and SAB all have the ability to increase the production of collagen in Detroit 551 cells. The results also confirmed that DSU and SAB can attenuate the α-MSH-stimulated melanin production of B16 cells by inhibiting tyrosinase activity. Therefore, SME, DSU and SAB each have the potential to be utilized as active ingredients in wound healing or cosmetic treatments. In the future, DSU and SAB could also be used as functional components for treating hyperpigmentation.
Keywords: collagenesis; danshensu; melanogenesis; salvianolic acid B; Salvia miltiorrhiza collagenesis; danshensu; melanogenesis; salvianolic acid B; Salvia miltiorrhiza
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, Y.-S.; Lee, S.-M.; Lin, Y.-J.; Chiang, S.-H.; Lin, C.-C. Effects of Danshensu and Salvianolic Acid B from Salvia miltiorrhiza Bunge (Lamiaceae) on Cell Proliferation and Collagen and Melanin Production. Molecules 2014, 19, 2029-2041.

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