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Molecules 2014, 19(2), 1843-1855; doi:10.3390/molecules19021843
Article

Antiproliferative Activity and Induction of Apoptosis in PC-3 Cells by the Chalcone Cardamonin from Campomanesia adamantium (Myrtaceae) in a Bioactivity-Guided Study

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1 Graduate Program in Biosciences and Technology of Bioactive Products, Pharmacy course, Department of Plant Biology, Institute of Biology, State University of Campinas-UNICAMP, 6109, Campinas 13083-970, São Paulo, Brazil 2 Department of Chemistry, Federal University of Paraná, 19081, Curitiba 81531-990, Paraná, Brazil 3 Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas-UNICAMP, Campinas 13083-887, São Paulo, Brazil 4 Faculty of Basic Sciences, Fluminense Federal University, Nova Friburgo 24020-420, Rio de Janeiro, Brazil 5 Multidisciplinary Center for Biological Research, Laboratory Animal Quality Control, State University of Campinas-UNICAMP, l6095, Campinas 13083-877, São Paulo, Brazil 6 Division of Pharmacology and Toxicology, Multidisciplinary Center for Chemical, Biological and Agricultural, State University of Campinas-UNICAMP, 6171, Campinas 13081-970, São Paulo, Brazil
* Author to whom correspondence should be addressed.
Received: 3 January 2014 / Revised: 31 January 2014 / Accepted: 3 February 2014 / Published: 7 February 2014
(This article belongs to the Section Metabolites)
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Abstract

The Myrtaceae family is a common source of medicines used in the treatment of numerous diseases in South America. In Brazil, fruits of the Campomanesia species are widely used to make liqueurs, juices and sweets, whereas leaves are traditionally employed as a medicine for dysentery, stomach problems, diarrhea, cystitis and urethritis. Ethanol extracts of Campomanesia adamantium (Myrtaceae) leaves and fruits were evaluated against prostate cancer cells (PC-3). The compound (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one, cardamonin) was isolated from ethanol extracts of C. adamantium leaves in a bioactivity-guided study and quantified by UPLC-MS/MS. In vitro studies showed that the isolated chalcone cardamonin inhibited prostate cancer cell proliferation and decreased the expression of NFkB1. Moreover, analysis by flow cytometry showed that this compound induced DNA fragmentation, suggesting an effect on apoptosis induction in the PC-3 cell line.
Keywords: Campomanesia adamantium; Myrtaceae; chalcone; cardamonin; apoptosis; cancer Campomanesia adamantium; Myrtaceae; chalcone; cardamonin; apoptosis; cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pascoal, A.C.R.F.; Ehrenfried, C.A.; Lopez, B.G.-C.; de Araujo, T.M.; Pascoal, V.D.B.; Gilioli, R.; Anhê, G.F.; Ruiz, A.L.T.G.; Carvalho, J.E.; Stefanello, M.É.A.; Salvador, M.J. Antiproliferative Activity and Induction of Apoptosis in PC-3 Cells by the Chalcone Cardamonin from Campomanesia adamantium (Myrtaceae) in a Bioactivity-Guided Study. Molecules 2014, 19, 1843-1855.

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