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Molecules 2014, 19(2), 1820-1827; doi:10.3390/molecules19021820
Article

Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana

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Received: 30 December 2013 / Revised: 21 January 2014 / Accepted: 27 January 2014 / Published: 6 February 2014
(This article belongs to the Section Metabolites)
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Abstract

Bioassay-guided fractionation of an ethanol extract of the pericarps of Garcinia mangostana led to the isolation of two new prenylated xanthones, named 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)-8-(3-hydroxy-3-methylbutyl)-xanthone (1) and 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (2), together with the five known compounds garcinones C (3) and D (4), gartanin (5), xanthone I (6), and γ-mangostin (7). Their structures were elucidated primarily based on MS and NMR data. Compounds 17 showed significant cytotoxic activities against various human cancer cell lines.
Keywords: Garcinia mangostana; xanthones; cytotoxic activities Garcinia mangostana; xanthones; cytotoxic activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xu, Z.; Huang, L.; Chen, X.-H.; Zhu, X.-F.; Qian, X.-J.; Feng, G.-K.; Lan, W.-J.; Li, H.-J. Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana. Molecules 2014, 19, 1820-1827.

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