Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana
AbstractBioassay-guided fractionation of an ethanol extract of the pericarps of Garcinia mangostana led to the isolation of two new prenylated xanthones, named 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)-8-(3-hydroxy-3-methylbutyl)-xanthone (1) and 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (2), together with the five known compounds garcinones C (3) and D (4), gartanin (5), xanthone I (6), and γ-mangostin (7). Their structures were elucidated primarily based on MS and NMR data. Compounds 1–7 showed significant cytotoxic activities against various human cancer cell lines.
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Xu, Z.; Huang, L.; Chen, X.-H.; Zhu, X.-F.; Qian, X.-J.; Feng, G.-K.; Lan, W.-J.; Li, H.-J. Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana. Molecules 2014, 19, 1820-1827.
Xu Z, Huang L, Chen X-H, Zhu X-F, Qian X-J, Feng G-K, Lan W-J, Li H-J. Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana. Molecules. 2014; 19(2):1820-1827.Chicago/Turabian Style
Xu, Zeng; Huang, Lei; Chen, Xiao-Hong; Zhu, Xiao-Feng; Qian, Xiao-Jun; Feng, Gong-Kan; Lan, Wen-Jian; Li, Hou-Jin. 2014. "Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana." Molecules 19, no. 2: 1820-1827.