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Molecules 2014, 19(2), 1820-1827; doi:10.3390/molecules19021820

Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana

School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China
Instrumental Analysis and Research Center, Sun Yat-Sen University, Guangzhou 510275, China
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China
Authors to whom correspondence should be addressed.
Received: 30 December 2013 / Revised: 21 January 2014 / Accepted: 27 January 2014 / Published: 6 February 2014
(This article belongs to the Section Natural Products)
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Bioassay-guided fractionation of an ethanol extract of the pericarps of Garcinia mangostana led to the isolation of two new prenylated xanthones, named 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)-8-(3-hydroxy-3-methylbutyl)-xanthone (1) and 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (2), together with the five known compounds garcinones C (3) and D (4), gartanin (5), xanthone I (6), and γ-mangostin (7). Their structures were elucidated primarily based on MS and NMR data. Compounds 17 showed significant cytotoxic activities against various human cancer cell lines.
Keywords: Garcinia mangostana; xanthones; cytotoxic activities Garcinia mangostana; xanthones; cytotoxic activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Xu, Z.; Huang, L.; Chen, X.-H.; Zhu, X.-F.; Qian, X.-J.; Feng, G.-K.; Lan, W.-J.; Li, H.-J. Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana. Molecules 2014, 19, 1820-1827.

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