Molecules 2014, 19(2), 1786-1794; doi:10.3390/molecules19021786
Article

A Pair of New Antioxidant Phenolic Acid Stereoisomers Isolated from Danshen Injection (Lyophilized Powder)

National Institutes for Food and Drug Control, Beijing 100050, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 17 December 2013; in revised form: 27 January 2014 / Accepted: 29 January 2014 / Published: 4 February 2014
(This article belongs to the Section Natural Products)
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Abstract: A pair of new phenolic acid stereoisomers, (R)-norsalvianolic acid L (1) and (S)-norsalvianolic acid L (2), was isolated from the Danshen Injection (lyophilized powder). The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods including 1D, 2D NMR (1H-1H COSY, HSQC and HMBC) and circular dichroism experiments. Their antioxidant activities were assessed by the DPPH· and ABTS·+ scavenging methods in vitro with microplate assay. The IC50 values of 1 were 6.9 and 9.7 μM respectively, which was close to the control salvianolic acid B (7.8 and 7.1 μM respectively), while the IC50 values of isomer 2 were 27.1 and 25.3 μM, respectively.
Keywords: Danshen Injection; phenolic acid; stereoisomer; antioxidant activity

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MDPI and ACS Style

Liu, J.; Zhao, J.; Dai, Z.; Lin, R.; Wang, G.; Ma, S. A Pair of New Antioxidant Phenolic Acid Stereoisomers Isolated from Danshen Injection (Lyophilized Powder). Molecules 2014, 19, 1786-1794.

AMA Style

Liu J, Zhao J, Dai Z, Lin R, Wang G, Ma S. A Pair of New Antioxidant Phenolic Acid Stereoisomers Isolated from Danshen Injection (Lyophilized Powder). Molecules. 2014; 19(2):1786-1794.

Chicago/Turabian Style

Liu, Jing; Zhao, Jianfeng; Dai, Zhong; Lin, Ruichao; Wang, Gangli; Ma, Shuangcheng. 2014. "A Pair of New Antioxidant Phenolic Acid Stereoisomers Isolated from Danshen Injection (Lyophilized Powder)." Molecules 19, no. 2: 1786-1794.

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