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Molecules 2014, 19(2), 1786-1794; doi:10.3390/molecules19021786

A Pair of New Antioxidant Phenolic Acid Stereoisomers Isolated from Danshen Injection (Lyophilized Powder)

National Institutes for Food and Drug Control, Beijing 100050, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 17 December 2013 / Revised: 27 January 2014 / Accepted: 29 January 2014 / Published: 4 February 2014
(This article belongs to the Section Natural Products)
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A pair of new phenolic acid stereoisomers, (R)-norsalvianolic acid L (1) and (S)-norsalvianolic acid L (2), was isolated from the Danshen Injection (lyophilized powder). The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods including 1D, 2D NMR (1H-1H COSY, HSQC and HMBC) and circular dichroism experiments. Their antioxidant activities were assessed by the DPPH· and ABTS·+ scavenging methods in vitro with microplate assay. The IC50 values of 1 were 6.9 and 9.7 μM respectively, which was close to the control salvianolic acid B (7.8 and 7.1 μM respectively), while the IC50 values of isomer 2 were 27.1 and 25.3 μM, respectively.
Keywords: Danshen Injection; phenolic acid; stereoisomer; antioxidant activity Danshen Injection; phenolic acid; stereoisomer; antioxidant activity

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Liu, J.; Zhao, J.; Dai, Z.; Lin, R.; Wang, G.; Ma, S. A Pair of New Antioxidant Phenolic Acid Stereoisomers Isolated from Danshen Injection (Lyophilized Powder). Molecules 2014, 19, 1786-1794.

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