Molecules 2014, 19(2), 1786-1794; doi:10.3390/molecules19021786
Article

A Pair of New Antioxidant Phenolic Acid Stereoisomers Isolated from Danshen Injection (Lyophilized Powder)

Received: 17 December 2013; in revised form: 27 January 2014 / Accepted: 29 January 2014 / Published: 4 February 2014
(This article belongs to the Section Natural Products)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A pair of new phenolic acid stereoisomers, (R)-norsalvianolic acid L (1) and (S)-norsalvianolic acid L (2), was isolated from the Danshen Injection (lyophilized powder). The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods including 1D, 2D NMR (1H-1H COSY, HSQC and HMBC) and circular dichroism experiments. Their antioxidant activities were assessed by the DPPH· and ABTS·+ scavenging methods in vitro with microplate assay. The IC50 values of 1 were 6.9 and 9.7 μM respectively, which was close to the control salvianolic acid B (7.8 and 7.1 μM respectively), while the IC50 values of isomer 2 were 27.1 and 25.3 μM, respectively.
Keywords: Danshen Injection; phenolic acid; stereoisomer; antioxidant activity
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MDPI and ACS Style

Liu, J.; Zhao, J.; Dai, Z.; Lin, R.; Wang, G.; Ma, S. A Pair of New Antioxidant Phenolic Acid Stereoisomers Isolated from Danshen Injection (Lyophilized Powder). Molecules 2014, 19, 1786-1794.

AMA Style

Liu J, Zhao J, Dai Z, Lin R, Wang G, Ma S. A Pair of New Antioxidant Phenolic Acid Stereoisomers Isolated from Danshen Injection (Lyophilized Powder). Molecules. 2014; 19(2):1786-1794.

Chicago/Turabian Style

Liu, Jing; Zhao, Jianfeng; Dai, Zhong; Lin, Ruichao; Wang, Gangli; Ma, Shuangcheng. 2014. "A Pair of New Antioxidant Phenolic Acid Stereoisomers Isolated from Danshen Injection (Lyophilized Powder)." Molecules 19, no. 2: 1786-1794.

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