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Molecules 2014, 19(12), 21215-21225; doi:10.3390/molecules191221215

Chemical Constituents from Licania cruegeriana and Their Cardiovascular and Antiplatelet Effects

1
Centro de Biofisica y Bioquímica, Instituto Venezolano de Investigaciones Científicas (IVIC), Altos de Pipe 1020-A, Venezuela
2
Facultad de Agronomía, Universidad Central de Venezuela, Maracay 2101, Venezuela
*
Author to whom correspondence should be addressed.
Received: 8 October 2014 / Revised: 13 November 2014 / Accepted: 14 November 2014 / Published: 17 December 2014
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Three new lupane-type triterpenoids: 6β,30-dihydroxybetulinic acid glucopyranosyl ester (4), 6β,30-dihydroxybetulinic acid (5) and 6β-hydroxybetulinic acid (6), were isolated from Licania cruegeriana Urb. along with six known compounds. Their structures were elucidated on the basis of spectroscopic methods, including IR, ESIMS, 1D- and 2D-NMR experiments, as well as by comparison of their spectral data with those of related compounds. All compounds were evaluated in vivo for their effects on the mean arterial blood pressure (MABP) and heart rate (HR) of spontaneously hypertensive rats (SHR) and also in vitro for their capacity to inhibit the human platelet aggregation. None of the isolated flavonoids 13 showed cardiovascular effects on SHR and among the isolated triterpenoids 49 only 5 and 6 produced a significant reduction in MABP (60.1% and 17.2%, respectively) and an elevation in HR (11.0% and 41.2%, respectively). Compounds 3, 4, 5 and 6 were able to inhibit human platelet aggregation induced by ADP, collagen and arachidonic acid with different selectivity profiles. View Full-Text
Keywords: lupane-type triterpenoids; Licania cruegeriana; platelet aggregation; SHR lupane-type triterpenoids; Licania cruegeriana; platelet aggregation; SHR
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Estrada, O.; Contreras, W.; Acha, G.; Lucena, E.; Venturini, W.; Cardozo, A.; Alvarado-Castillo, C. Chemical Constituents from Licania cruegeriana and Their Cardiovascular and Antiplatelet Effects. Molecules 2014, 19, 21215-21225.

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