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Molecules 2014, 19(10), 16458-16476; doi:10.3390/molecules191016458

Bioactivity and Chemical Synthesis of Caffeic Acid Phenethyl Ester and Its Derivatives

1,2, 1,2,3,* , 1,* , 1,2,3 and 1,2,3
1
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
2
Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China
3
National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
*
Authors to whom correspondence should be addressed.
Received: 15 September 2014 / Revised: 3 October 2014 / Accepted: 9 October 2014 / Published: 13 October 2014
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Abstract

Caffeic acid phenethyl ester (CAPE), as one of the main active ingredients of the natural product propolis, shows the unique biological activities such as anti-tumor, anti-oxidation, anti-inflammatory, immune regulation, and so on. These have attracted the attention of many researchers to explore the compound with potent biological activities. This review aims to summarize its bioactivities, synthetic methods and derivatives, which will be helpful for further study and development of CAPE and its derivatives. View Full-Text
Keywords: caffeic acid phenethyl ester; chemical structure; biological; synthetic method; structural modification caffeic acid phenethyl ester; chemical structure; biological; synthetic method; structural modification
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Zhang, P.; Tang, Y.; Li, N.-G.; Zhu, Y.; Duan, J.-A. Bioactivity and Chemical Synthesis of Caffeic Acid Phenethyl Ester and Its Derivatives. Molecules 2014, 19, 16458-16476.

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