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Molecules 2014, 19(10), 16102-16121; doi:10.3390/molecules191016102

Resveratrol and Endothelial Nitric Oxide

Department of Pharmacology, Johannes Gutenberg University Medical Center, Obere Zahlbacher Str. 67, Mainz 55131, Germany
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Received: 18 August 2014 / Revised: 21 September 2014 / Accepted: 25 September 2014 / Published: 9 October 2014
(This article belongs to the Special Issue Resveratrol)
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Abstract

Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resveratrol involve SIRT1, AMPK, Nrf2 and estrogen receptors. View Full-Text
Keywords: resveratrol; nitric oxide; eNOS; SIRT1; Nrf2 resveratrol; nitric oxide; eNOS; SIRT1; Nrf2
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xia, N.; Förstermann, U.; Li, H. Resveratrol and Endothelial Nitric Oxide. Molecules 2014, 19, 16102-16121.

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