Two New Phenolic Compounds from the Heartwood of Caesalpinia sappan L.
Abstract
:1. Introduction
2. Results and Discussion
No. | 1 (in DMSO-d6) | 1 (in CD3OD) | 2 (in CD3OD) | |||
---|---|---|---|---|---|---|
δC | δH | δC | δH | δC | δH | |
1 | 146.3 | 7.03 d (10.0) | 149.0 | 7.16 d (10.0) | 151.5 | 6.88 d (10.0) |
2 | 129.2 | 6.46 dd (10.0, 1.5) | 130.4 | 6.51 dd (10.0, 1.5) | 128.5 | 6.45 dd (10.0, 1.5) |
3 | 187.1 | 190.9 | 191.4 | |||
4 | 108.5 | 5.48 d (1.5) | 109.8 | 5.57 d (1.5) | 108.1 | 5.58 d (1.5) |
4a | 175.0 | 178.6 | 179.7 | |||
6 | 77.8 | 4.12 d (11.0) | 79.8 | 4.18 d (11.0) | 81.0 | 3.88 dd (11.0) |
3.72 d (11.0) | 3.79 d (11.0) | 4.27 dd (11.0) | ||||
7 | 69.4 | 71.3 | 66.8 | |||
8 | 37.6 | 3.16 d (16.0) | 39.0 | 3.30 d (16.0) | 43.5 | 3.16 d (16.0) |
2.83 d (16.0) | 2.88 d (16.0) | 3.10 d (16.0) | ||||
8a | 122.6 | 124.2 | 129.5 | |||
9 | 115.4 | 6.52 s | 116.6 | 6.59 s | 116.9 | 6.64 s |
10 | 145.0 | 146.6 | 146.8 | |||
11 | 143.6 | 145.2 | 145.1 | |||
12 | 112.9 | 6.26 s | 114.1 | 6.35 s | 113.4 | 6.44 s |
12a | 126.6 | 128.5 | 125.5 | |||
12b | 51.1 | 53.5 | 47.8 | |||
13 | 82.7 | 3.44 s | 84.8 | 3.48 s | 41.1 | 1.99 dd (11.5) |
2.34 dd (11.5) | ||||||
OCH3 | 61.4 | 3.53 s | 62.6 | 3.62 s | - | - |
Compound | Viability (at 50 µM, %) | IC50 (µM) | Compound | Viability (at 50 µM, %) | IC50(µM) |
---|---|---|---|---|---|
1 | 96.45 | 52.62 | 6 | 101.64 | 21.46 |
2 | 99.29 | 56.71 | 7 | 94.00 | 15.46 |
3 | 96.13 | 45.87 | 8 | 99.29 | 8.26 |
4 | 98.94 | 14.23 | quercetin | 23.42 | |
5 | 101.19 | 28.65 |
3. Experimental
3.1. General
3.2. Plant Material
3.3. Extraction and Isolation
3.4. Spectral Data
3.5. Inhibition of NO Production in LPS-Stimulated BV-2 Microglia
4. Conclusions
Acknowledgments
Conflicts of Interest
References
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- Sample Availability: Not available.
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Zhao, M.-B.; Li, J.; Shi, S.-P.; Cai, C.-Q.; Tu, P.-F.; Tang, L.; Zeng, K.-W.; Jiang, Y. Two New Phenolic Compounds from the Heartwood of Caesalpinia sappan L. Molecules 2014, 19, 1-8. https://doi.org/10.3390/molecules19010001
Zhao M-B, Li J, Shi S-P, Cai C-Q, Tu P-F, Tang L, Zeng K-W, Jiang Y. Two New Phenolic Compounds from the Heartwood of Caesalpinia sappan L. Molecules. 2014; 19(1):1-8. https://doi.org/10.3390/molecules19010001
Chicago/Turabian StyleZhao, Ming-Bo, Jun Li, She-Po Shi, Chen-Qiu Cai, Peng-Fei Tu, Li Tang, Ke-Wu Zeng, and Yong Jiang. 2014. "Two New Phenolic Compounds from the Heartwood of Caesalpinia sappan L." Molecules 19, no. 1: 1-8. https://doi.org/10.3390/molecules19010001