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Molecules 2013, 18(9), 10944-10952; doi:10.3390/molecules180910944
Article

Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68)

1
, 2,1,* , 3
, 4
 and 5,*
1 Key Laboratory of wood science and Technology of State Forestry Administration, Research Institute of Wood Industry, Chinese Academy of forestry, Beijing 100091, China 2 School of Technology, Beijing Forestry University, Beijing 100091, China 3 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China 4 State Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China 5 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
* Authors to whom correspondence should be addressed.
Received: 22 July 2013 / Revised: 28 August 2013 / Accepted: 2 September 2013 / Published: 5 September 2013
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Abstract

Chaetochromones A (1) and B (2), two novel polyketides, were isolated from the crude extract of fungus Chaetomium indicum (CBS.860.68) together with three known analogues PI-3(3), PI-4 (4) and SB236050 (5). The structures of these compounds were determined by HRESI-MS and NMR experiments. Chaetochromones A (1) and B (2) are a member of the polyketides family, which might originate from a similar biogenetic pathway as the known compounds PI-3 (3), PI-4 (4) and SB236050 (5). The biological activities of these secondary metabolites were evaluated against eight plant pathogens, including Alternaria alternata, Ilyonectria radicicola, Trichoderma viride pers, Aspergillus niger, Fusarium verticillioide, Irpex lacteus (Fr.), Poria placenta (Fr.) Cooke and Coriolus versicolor (L.) Quél. Compound 1 displayed moderate inhibitory rate (>60%) against the brown rot fungus Poria placenta (Fr.) Cooke, which causes significant wood decay. In addition, the cytotoxic activities against three cancer cell lines A549, MDA-MB-231, PANC-1 were also tested, without any inhibitory activities being detected.
Keywords: Chaetomium indicum; polyketides; chaetochromones; plant pathogens; wood decay Chaetomium indicum; polyketides; chaetochromones; plant pathogens; wood decay
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lu, K.; Zhang, Y.; Li, L.; Wang, X.; Ding, G. Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68). Molecules 2013, 18, 10944-10952.

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