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Molecules 2013, 18(9), 10944-10952; doi:10.3390/molecules180910944
Article

Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68)

1
, 2,1,* , 3
, 4
 and 5,*
Received: 22 July 2013; in revised form: 28 August 2013 / Accepted: 2 September 2013 / Published: 5 September 2013
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Abstract: Chaetochromones A (1) and B (2), two novel polyketides, were isolated from the crude extract of fungus Chaetomium indicum (CBS.860.68) together with three known analogues PI-3(3), PI-4 (4) and SB236050 (5). The structures of these compounds were determined by HRESI-MS and NMR experiments. Chaetochromones A (1) and B (2) are a member of the polyketides family, which might originate from a similar biogenetic pathway as the known compounds PI-3 (3), PI-4 (4) and SB236050 (5). The biological activities of these secondary metabolites were evaluated against eight plant pathogens, including Alternaria alternata, Ilyonectria radicicola, Trichoderma viride pers, Aspergillus niger, Fusarium verticillioide, Irpex lacteus (Fr.), Poria placenta (Fr.) Cooke and Coriolus versicolor (L.) Quél. Compound 1 displayed moderate inhibitory rate (>60%) against the brown rot fungus Poria placenta (Fr.) Cooke, which causes significant wood decay. In addition, the cytotoxic activities against three cancer cell lines A549, MDA-MB-231, PANC-1 were also tested, without any inhibitory activities being detected.
Keywords: Chaetomium indicum; polyketides; chaetochromones; plant pathogens; wood decay Chaetomium indicum; polyketides; chaetochromones; plant pathogens; wood decay
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lu, K.; Zhang, Y.; Li, L.; Wang, X.; Ding, G. Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68). Molecules 2013, 18, 10944-10952.

AMA Style

Lu K, Zhang Y, Li L, Wang X, Ding G. Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68). Molecules. 2013; 18(9):10944-10952.

Chicago/Turabian Style

Lu, Keyang; Zhang, Yisheng; Li, Li; Wang, Xuewei; Ding, Gang. 2013. "Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68)." Molecules 18, no. 9: 10944-10952.



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