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Molecules 2013, 18(8), 9594-9602; doi:10.3390/molecules18089594

A Facile Fabrication of Alginate Microbubbles Using a Gas Foaming Reaction

1 The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung 82445, Taiwan 2 Department of Applied Cosmetology and Master Program of Cosmetic Science, Hungkuang University, Taichung 43302, Taiwan 3 Department of Biological Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan
* Author to whom correspondence should be addressed.
Received: 17 July 2013 / Revised: 6 August 2013 / Accepted: 7 August 2013 / Published: 12 August 2013
(This article belongs to the Section Molecular Diversity)
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Microbubble particles have been extensively utilized as temporal templates for various biomedical applications. This study proposes a facile strategy to obtain microbubble-containing alginate particles (i.e., microbubbles inside alginate gel particles, called alginate microbubbles). The chemical reaction of sodium bicarbonate and hydrogen peroxide to produce gaseous carbon dioxide and oxygen was utilized to form microbubbles within alginate particles. Uniform alginate particles were obtained by a stable needle-based droplet formation process. Kinetic reaction of gas formation was monitored for 2% alginate particles. The gas formation increased with the concentrations of sodium bicarbonate (1–5 wt%) and hydrogen peroxide (0–36.5 wt%).
Keywords: microbubbles; alginate; gas; particle microbubbles; alginate; gas; particle
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Huang, K.-S.; Lin, Y.-S.; Chang, W.-R.; Wang, Y.-L.; Yang, C.-H. A Facile Fabrication of Alginate Microbubbles Using a Gas Foaming Reaction. Molecules 2013, 18, 9594-9602.

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