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A Facile Fabrication of Alginate Microbubbles Using a Gas Foaming Reaction
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung 82445, Taiwan
Department of Applied Cosmetology and Master Program of Cosmetic Science, Hungkuang University, Taichung 43302, Taiwan
Department of Biological Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan
* Author to whom correspondence should be addressed.
Received: 17 July 2013; in revised form: 6 August 2013 / Accepted: 7 August 2013 / Published: 12 August 2013
Abstract: Microbubble particles have been extensively utilized as temporal templates for various biomedical applications. This study proposes a facile strategy to obtain microbubble-containing alginate particles (i.e., microbubbles inside alginate gel particles, called alginate microbubbles). The chemical reaction of sodium bicarbonate and hydrogen peroxide to produce gaseous carbon dioxide and oxygen was utilized to form microbubbles within alginate particles. Uniform alginate particles were obtained by a stable needle-based droplet formation process. Kinetic reaction of gas formation was monitored for 2% alginate particles. The gas formation increased with the concentrations of sodium bicarbonate (1–5 wt%) and hydrogen peroxide (0–36.5 wt%).
Keywords: microbubbles; alginate; gas; particle
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Huang, K.-S.; Lin, Y.-S.; Chang, W.-R.; Wang, Y.-L.; Yang, C.-H. A Facile Fabrication of Alginate Microbubbles Using a Gas Foaming Reaction. Molecules 2013, 18, 9594-9602.
Huang K-S, Lin Y-S, Chang W-R, Wang Y-L, Yang C-H. A Facile Fabrication of Alginate Microbubbles Using a Gas Foaming Reaction. Molecules. 2013; 18(8):9594-9602.
Huang, Keng-Shiang; Lin, Yung-Sheng; Chang, Wan-Ru; Wang, Yi-Ling; Yang, Chih-Hui. 2013. "A Facile Fabrication of Alginate Microbubbles Using a Gas Foaming Reaction." Molecules 18, no. 8: 9594-9602.