Molecules 2013, 18(8), 9420-9431; doi:10.3390/molecules18089420
Article

Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose

1 Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, Napoli 80131, Italy 2 Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Via Cintia 21, Napoli 80126, Italy
* Author to whom correspondence should be addressed.
Received: 27 May 2013; in revised form: 19 July 2013 / Accepted: 1 August 2013 / Published: 6 August 2013
(This article belongs to the Section Organic Synthesis)
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Abstract: The antiviral activity of certain acyclic nucleosides drew our attention to the fact that the replacement of the furanose ring by an alkyl group bearing hydroxyl(s) could be a useful structural modification to modulate the biological properties of those nucleosides. Herein, we report on the synthesis of some novel acadesine analogues, where the ribose moiety is mimicked by a d-ribityl or by a hydroxybutyl chain.
Keywords: AICAR; ZMP; acadesine; AMPK; AMPK activation; imidazole nucleosides; nucleoside analogues; modified nucleosides; acyclic nucleosides; acyclic nucleotides

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MDPI and ACS Style

D'Errico, S.; Oliviero, G.; Borbone, N.; Amato, J.; Piccialli, V.; Varra, M.; Mayol, L.; Piccialli, G. Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose. Molecules 2013, 18, 9420-9431.

AMA Style

D'Errico S, Oliviero G, Borbone N, Amato J, Piccialli V, Varra M, Mayol L, Piccialli G. Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose. Molecules. 2013; 18(8):9420-9431.

Chicago/Turabian Style

D'Errico, Stefano; Oliviero, Giorgia; Borbone, Nicola; Amato, Jussara; Piccialli, Vincenzo; Varra, Michela; Mayol, Luciano; Piccialli, Gennaro. 2013. "Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose." Molecules 18, no. 8: 9420-9431.

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