Next Article in Journal
Previous Article in Journal
Molecules 2013, 18(8), 9420-9431; doi:10.3390/molecules18089420
Article

Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose

1
, 1,* , 1
, 1
, 2
, 1
, 1
 and 1
Received: 27 May 2013; in revised form: 19 July 2013 / Accepted: 1 August 2013 / Published: 6 August 2013
(This article belongs to the Section Organic Synthesis)
Download PDF [234 KB, uploaded 18 June 2014]
Abstract: The antiviral activity of certain acyclic nucleosides drew our attention to the fact that the replacement of the furanose ring by an alkyl group bearing hydroxyl(s) could be a useful structural modification to modulate the biological properties of those nucleosides. Herein, we report on the synthesis of some novel acadesine analogues, where the ribose moiety is mimicked by a d-ribityl or by a hydroxybutyl chain.
Keywords: AICAR; ZMP; acadesine; AMPK; AMPK activation; imidazole nucleosides; nucleoside analogues; modified nucleosides; acyclic nucleosides; acyclic nucleotides AICAR; ZMP; acadesine; AMPK; AMPK activation; imidazole nucleosides; nucleoside analogues; modified nucleosides; acyclic nucleosides; acyclic nucleotides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

D'Errico, S.; Oliviero, G.; Borbone, N.; Amato, J.; Piccialli, V.; Varra, M.; Mayol, L.; Piccialli, G. Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose. Molecules 2013, 18, 9420-9431.

AMA Style

D'Errico S, Oliviero G, Borbone N, Amato J, Piccialli V, Varra M, Mayol L, Piccialli G. Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose. Molecules. 2013; 18(8):9420-9431.

Chicago/Turabian Style

D'Errico, Stefano; Oliviero, Giorgia; Borbone, Nicola; Amato, Jussara; Piccialli, Vincenzo; Varra, Michela; Mayol, Luciano; Piccialli, Gennaro. 2013. "Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose." Molecules 18, no. 8: 9420-9431.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert