Next Article in Journal
Amazonian Plant Natural Products: Perspectives for Discovery of New Antimalarial Drug Leads
Previous Article in Journal
Inhibition of Lipopolysaccharide-Induced Proinflammatory Responses by Buddleja officinalis Extract in BV-2 Microglial Cells via Negative Regulation of NF-kB and ERK1/2 Signaling
Molecules 2013, 18(8), 9207-9218; doi:10.3390/molecules18089207

In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia

1,* , 1,2
1 Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 2 Department of Pharmacognosy, Faculty of Pharmacy, Sana'a University, P.O. Box 33039, Sana'a, Yemen 3 Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Antwerp B-2610, Belgium
* Author to whom correspondence should be addressed.
Received: 15 July 2013 / Revised: 28 July 2013 / Accepted: 29 July 2013 / Published: 31 July 2013
(This article belongs to the Section Metabolites)
Download PDF [320 KB, uploaded 18 June 2014]


Two lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 36 were isolated for the first time from K. odora. The triterpene constituents were investigated for antiprotozoal potential against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxicity was determined against MRC-5 fibroblasts to assess selectivity. The ursane triterpenes were found to be active against more than one type of the tested parasites, with the exception of compound 6. This is also the first report on the occurrence of ursane type triterpenes in the genus Kleinia and their antiprotozoal potential against P. falciparum, L. infantum, T. cruzi, and T. brucei.
Keywords: Kleinia odora; triterpenes; antiplasmodial; antileishmanial; antitrypanosomal Kleinia odora; triterpenes; antiplasmodial; antileishmanial; antitrypanosomal
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Al Musayeib, N.M.; Mothana, R.A.; Gamal, A.A.E.; Al-Massarani, S.M.; Maes, L. In Vitro Antiprotozoal Activity of Triterpenoid Constituents of Kleinia odora Growing in Saudi Arabia. Molecules 2013, 18, 9207-9218.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert