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Antidiarrheal Activity of 19-Deoxyicetexone Isolated from Salvia ballotiflora Benth in Mice and Rats
Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana. Unidad Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, Coyoacán 04960, Mexico
Doctorado en Biología Experimental. D.C.B.S. Universidad Autónoma Metropolitana. Unidad Iztapalapa, Av. San Rafael Atlixco No. 186 Col. Vicentina, Iztapalapa 09340, Mexico
Centro de Química, ICUAP, Benemérita Universidad Autónoma de Puebla, Ciudad Universitaria Puebla 72592, Mexico
* Author to whom correspondence should be addressed.
Received: 16 June 2013; in revised form: 17 July 2013 / Accepted: 23 July 2013 / Published: 26 July 2013
Abstract: The antidiarrheal properties of 19-deoxyicetexone, a diterpenoid isolated from Salvia ballotiflora were evaluated on castor oil-, arachidonic acid (AA)- and prostaglandin (PGE2)-induced diarrhea in rodent models. The structure of 19-deoxyicetexone was determined by X-ray crystallography, mass spectrometry (EI-MS), as well as ultraviolet (UV-Vis), infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopies. This compound significantly and dose-dependently reduced frequency of stooling in castor oil-induced diarrhea, and at dose of 25 mg/kg it also inhibited diarrhea induced with AA, while it had no effect on PGE2-induced diarrhea. This compound at doses of 25 mg/kg also diminished castor oil-induced enteropooling and intestinal motility, and inhibited the contraction of the rats’ ileum induced by carbachol chloride at a concentration of 100 µg/mL. 19-Deoxyicetexone did not present acute toxicity at doses of 625 mg/kg. Its antidiarrheal activity may be due to increased reabsorption of NaCl and water and inhibition of the release of prostaglandins, gastrointestinal motility and fluid accumulation in the intestinal tracts of rats. These findings suggest that 19-deoxyicetexone may be used in the treatment of diarrhea, although more studies must be carried out to confirm this.
Keywords: Salvia ballotiflora; antidiarrheal activity; 19-deoxyicetexone
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Pérez-Gutiérrez, S.; Zavala-Mendoza, D.; Hernández-Munive, A.; Mendoza-Martínez, Á.; Pérez-González, C.; Sánchez-Mendoza, E. Antidiarrheal Activity of 19-Deoxyicetexone Isolated from Salvia ballotiflora Benth in Mice and Rats. Molecules 2013, 18, 8895-8905.
Pérez-Gutiérrez S, Zavala-Mendoza D, Hernández-Munive A, Mendoza-Martínez Á, Pérez-González C, Sánchez-Mendoza E. Antidiarrheal Activity of 19-Deoxyicetexone Isolated from Salvia ballotiflora Benth in Mice and Rats. Molecules. 2013; 18(8):8895-8905.
Pérez-Gutiérrez, Salud; Zavala-Mendoza, Daniel; Hernández-Munive, Abigail; Mendoza-Martínez, Ángel; Pérez-González, Cuauhtemoc; Sánchez-Mendoza, Ernesto. 2013. "Antidiarrheal Activity of 19-Deoxyicetexone Isolated from Salvia ballotiflora Benth in Mice and Rats." Molecules 18, no. 8: 8895-8905.