Next Article in Journal
Previous Article in Journal
Molecules 2013, 18(8), 8895-8905; doi:10.3390/molecules18088895
Article

Antidiarrheal Activity of 19-Deoxyicetexone Isolated from Salvia ballotiflora Benth in Mice and Rats

1, 2, 1, 3, 1 and 1,*
Received: 16 June 2013; in revised form: 17 July 2013 / Accepted: 23 July 2013 / Published: 26 July 2013
(This article belongs to the Section Metabolites)
Download PDF [423 KB, uploaded 18 June 2014]
Abstract: The antidiarrheal properties of 19-deoxyicetexone, a diterpenoid isolated from Salvia ballotiflora were evaluated on castor oil-, arachidonic acid (AA)- and prostaglandin (PGE2)-induced diarrhea in rodent models. The structure of 19-deoxyicetexone was determined by X-ray crystallography, mass spectrometry (EI-MS), as well as ultraviolet (UV-Vis), infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopies. This compound significantly and dose-dependently reduced frequency of stooling in castor oil-induced diarrhea, and at dose of 25 mg/kg it also inhibited diarrhea induced with AA, while it had no effect on PGE2-induced diarrhea. This compound at doses of 25 mg/kg also diminished castor oil-induced enteropooling and intestinal motility, and inhibited the contraction of the rats’ ileum induced by carbachol chloride at a concentration of 100 µg/mL. 19-Deoxyicetexone did not present acute toxicity at doses of 625 mg/kg. Its antidiarrheal activity may be due to increased reabsorption of NaCl and water and inhibition of the release of prostaglandins, gastrointestinal motility and fluid accumulation in the intestinal tracts of rats. These findings suggest that 19-deoxyicetexone may be used in the treatment of diarrhea, although more studies must be carried out to confirm this.
Keywords: Salvia ballotiflora; antidiarrheal activity; 19-deoxyicetexone Salvia ballotiflora; antidiarrheal activity; 19-deoxyicetexone
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Pérez-Gutiérrez, S.; Zavala-Mendoza, D.; Hernández-Munive, A.; Mendoza-Martínez, Á.; Pérez-González, C.; Sánchez-Mendoza, E. Antidiarrheal Activity of 19-Deoxyicetexone Isolated from Salvia ballotiflora Benth in Mice and Rats. Molecules 2013, 18, 8895-8905.

AMA Style

Pérez-Gutiérrez S, Zavala-Mendoza D, Hernández-Munive A, Mendoza-Martínez Á, Pérez-González C, Sánchez-Mendoza E. Antidiarrheal Activity of 19-Deoxyicetexone Isolated from Salvia ballotiflora Benth in Mice and Rats. Molecules. 2013; 18(8):8895-8905.

Chicago/Turabian Style

Pérez-Gutiérrez, Salud; Zavala-Mendoza, Daniel; Hernández-Munive, Abigail; Mendoza-Martínez, Ángel; Pérez-González, Cuauhtemoc; Sánchez-Mendoza, Ernesto. 2013. "Antidiarrheal Activity of 19-Deoxyicetexone Isolated from Salvia ballotiflora Benth in Mice and Rats." Molecules 18, no. 8: 8895-8905.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert