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Molecules 2013, 18(8), 8812-8836; doi:10.3390/molecules18088812
Article

Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity

1,* , 2, 3, 4, 3 and 5
Received: 29 May 2013; in revised form: 12 July 2013 / Accepted: 15 July 2013 / Published: 24 July 2013
(This article belongs to the Section Organic Synthesis)
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Abstract: Thirty two new Cu(II), Ni(II) and Zn(II) complexes (132) with salicylidene thiosemicarbazones (H2L1H2L10) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C6H5). The characterization of the new formed compounds was done by 1H-NMR, 13C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.
Keywords: copper; nickel; zinc complexes; thiosemicarbazones; antimicrobial activity; antileukemia copper; nickel; zinc complexes; thiosemicarbazones; antimicrobial activity; antileukemia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pahontu, E.; Fala, V.; Gulea, A.; Poirier, D.; Tapcov, V.; Rosu, T. Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity. Molecules 2013, 18, 8812-8836.

AMA Style

Pahontu E, Fala V, Gulea A, Poirier D, Tapcov V, Rosu T. Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity. Molecules. 2013; 18(8):8812-8836.

Chicago/Turabian Style

Pahontu, Elena; Fala, Valeriu; Gulea, Aurelian; Poirier, Donald; Tapcov, Victor; Rosu, Tudor. 2013. "Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity." Molecules 18, no. 8: 8812-8836.



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