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Molecules 2013, 18(8), 8812-8836; doi:10.3390/molecules18088812
Article

Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity

1,* , 2, 3, 4, 3 and 5
1 Inorganic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", 6 Traian Vuia Street, 020956 Bucharest, Romania 2 Dental Education Department, Moldova State University of Medicine and Pharmacy "N. Testemitsanu" Chisinau, Republic of Moldova 3 Coordination Chemistry Department, Moldova State University, 60 Mateevici Street, 2009 Chisinau, Republic of Moldova 4 Laboratory of Medicinal Chemistry, CHUQ (CHUL)- Research Center and Université Laval, 2705 Boulevard Laurier, Québec City, QC G1V 4G2 Canada 5 Inorganic Chemistry Department, Faculty of Chemistry, University of Bucharest, 23 Dumbrava Rosie Street, 020462 Bucharest, Romania
* Author to whom correspondence should be addressed.
Received: 29 May 2013 / Revised: 12 July 2013 / Accepted: 15 July 2013 / Published: 24 July 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

Thirty two new Cu(II), Ni(II) and Zn(II) complexes (132) with salicylidene thiosemicarbazones (H2L1H2L10) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C6H5). The characterization of the new formed compounds was done by 1H-NMR, 13C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.
Keywords: copper; nickel; zinc complexes; thiosemicarbazones; antimicrobial activity; antileukemia copper; nickel; zinc complexes; thiosemicarbazones; antimicrobial activity; antileukemia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pahontu, E.; Fala, V.; Gulea, A.; Poirier, D.; Tapcov, V.; Rosu, T. Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity. Molecules 2013, 18, 8812-8836.

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