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Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb.
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
Endemic Species Research Institute, Council of Agriculture, Nantou 552, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 211, Taiwan
Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan
Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 404, Taiwan
* Author to whom correspondence should be addressed.
Received: 18 June 2013; in revised form: 11 July 2013 / Accepted: 21 July 2013 / Published: 24 July 2013
Abstract: Two new steroidal saponins, named drangustosides A–B (1–2), together with eight known compounds 3–10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB.
Keywords: Agavaceae; Dracaena angustifolia Roxb; steroidal saponins; drangustosides A–B; anti-inflammatory activity
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MDPI and ACS Style
Huang, H.-C.; Lin, M.-K.; Hwang, S.-Y.; Hwang, T.-L.; Kuo, Y.-H.; Chang, C.-I.; Ou, C.-Y.; Kuo, Y.-H. Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb.. Molecules 2013, 18, 8752-8763.
Huang H-C, Lin M-K, Hwang S-Y, Hwang T-L, Kuo Y-H, Chang C-I, Ou C-Y, Kuo Y-H. Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb.. Molecules. 2013; 18(8):8752-8763.
Huang, Hui-Chi; Lin, Ming-Kuem; Hwang, Syh-Yuan; Hwang, Tsong-Long; Kuo, Yao-Haur; Chang, Chi-I; Ou, Chung-Yi; Kuo, Yueh-Hsiung. 2013. "Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb.." Molecules 18, no. 8: 8752-8763.