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Molecules 2013, 18(8), 8752-8763; doi:10.3390/molecules18088752
Article

Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb.

1, 1, 2, 3, 4,5, 6, 7 and 1,8,*
1 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan 2 Endemic Species Research Institute, Council of Agriculture, Nantou 552, Taiwan 3 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 4 Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 211, Taiwan 5 Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan 6 Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan 7 Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan 8 Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 404, Taiwan
* Author to whom correspondence should be addressed.
Received: 18 June 2013 / Revised: 11 July 2013 / Accepted: 21 July 2013 / Published: 24 July 2013
(This article belongs to the Section Metabolites)
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Abstract

Two new steroidal saponins, named drangustosides A–B (12), together with eight known compounds 310 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB.
Keywords: Agavaceae; Dracaena angustifolia Roxb; steroidal saponins; drangustosides A–B; anti-inflammatory activity Agavaceae; Dracaena angustifolia Roxb; steroidal saponins; drangustosides A–B; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Huang, H.-C.; Lin, M.-K.; Hwang, S.-Y.; Hwang, T.-L.; Kuo, Y.-H.; Chang, C.-I.; Ou, C.-Y.; Kuo, Y.-H. Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb.. Molecules 2013, 18, 8752-8763.

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