Next Article in Journal
Hexachlorocyclotriphosphazene (HCCP)-Mediated Direct Formation of Thioethers and Ethers from Quinazolin-4(3H)-ones
Previous Article in Journal
Isotope Effects as Probes for Enzyme Catalyzed Hydrogen-Transfer Reactions
Molecules 2013, 18(5), 5568-5579; doi:10.3390/molecules18055568
Article

Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds

, , ,  and *
Received: 17 April 2013; in revised form: 9 May 2013 / Accepted: 10 May 2013 / Published: 14 May 2013
(This article belongs to the Section Metabolites)
Download PDF [675 KB, uploaded 18 June 2014]
Abstract: Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11)-diene-3a-29-diol 3-benzoate (5) exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells.
Keywords: Cucurbita maxima; multiflorane-type triterpenes; melanogenesis inhibitory activity; cytotoxic activity Cucurbita maxima; multiflorane-type triterpenes; melanogenesis inhibitory activity; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Kikuchi, T.; Takebayashi, M.; Shinto, M.; Yamada, T.; Tanaka, R. Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds. Molecules 2013, 18, 5568-5579.

AMA Style

Kikuchi T, Takebayashi M, Shinto M, Yamada T, Tanaka R. Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds. Molecules. 2013; 18(5):5568-5579.

Chicago/Turabian Style

Kikuchi, Takashi; Takebayashi, Mika; Shinto, Mayumi; Yamada, Takeshi; Tanaka, Reiko. 2013. "Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds." Molecules 18, no. 5: 5568-5579.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert