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Molecules 2013, 18(5), 5568-5579; doi:10.3390/molecules18055568
Article

Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds

, , ,  and *
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki-shi, Osaka 569-1094, Japan
* Author to whom correspondence should be addressed.
Received: 17 April 2013 / Revised: 9 May 2013 / Accepted: 10 May 2013 / Published: 14 May 2013
(This article belongs to the Section Metabolites)
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Abstract

Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11)-diene-3a-29-diol 3-benzoate (5) exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells.
Keywords: Cucurbita maxima; multiflorane-type triterpenes; melanogenesis inhibitory activity; cytotoxic activity Cucurbita maxima; multiflorane-type triterpenes; melanogenesis inhibitory activity; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kikuchi, T.; Takebayashi, M.; Shinto, M.; Yamada, T.; Tanaka, R. Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds. Molecules 2013, 18, 5568-5579.

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