Molecules 2013, 18(5), 5420-5433; doi:10.3390/molecules18055420
Article

Synthesis, Characterization and Activity Evaluation of Matrinic Acid Derivatives as Potential Antiproliferative Agents

1 College of Science, Northwest A&F University, Yangling 712100, China 2 College of Forestry, Northwest A&F University, Yangling 712100, China
* Authors to whom correspondence should be addressed.
Received: 1 April 2013; in revised form: 28 April 2013 / Accepted: 3 May 2013 / Published: 10 May 2013
(This article belongs to the Section Natural Products)
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Abstract: A series of new matrinic acid derivatives 5ae was synthesized. The chemical structures of the synthesized compounds were confirmed by 1H-NMR, 13C-NMR, and electrospray ionization mass spectroscopy. The anti-tumor activities were also investigated in vitro by evaluating the effect of synthesized compounds on the proliferation of A375, A549, HeLa, and HepG2 cells. Compound 5e was found to be the most potent against A375 and HeLa cells, with IC50 values of 37 and 75.5 μg/mL, respectively. Compounds 5b, 5c, 5g, and 5h also exhibited antiproliferative activities against A549 cells, with IC50 values within the 36.2–47 μg/mL range. For HepG2 cells, 5e and 5i, with IC50 values of 78.9 and 61 μg/mL, respectively, showed higher antiproliferative activity than taxol.
Keywords: matrinic acid derivative; synthesis; antiproliferative activity

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MDPI and ACS Style

Chao, F.; Wang, D.-E.; Liu, R.; Tu, Q.; Liu, J.-J.; Wang, J. Synthesis, Characterization and Activity Evaluation of Matrinic Acid Derivatives as Potential Antiproliferative Agents. Molecules 2013, 18, 5420-5433.

AMA Style

Chao F, Wang D-E, Liu R, Tu Q, Liu J-J, Wang J. Synthesis, Characterization and Activity Evaluation of Matrinic Acid Derivatives as Potential Antiproliferative Agents. Molecules. 2013; 18(5):5420-5433.

Chicago/Turabian Style

Chao, Fan; Wang, Dong-En; Liu, Rui; Tu, Qin; Liu, Jian-Jun; Wang, Jinyi. 2013. "Synthesis, Characterization and Activity Evaluation of Matrinic Acid Derivatives as Potential Antiproliferative Agents." Molecules 18, no. 5: 5420-5433.

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