Molecules 2013, 18(4), 4588-4598; doi:10.3390/molecules18044588
Article

Chemical Composition, Cytotoxic and Antimicrobial Activity of Essential Oils from Cassia bakeriana Craib. against Aerobic and Anaerobic Oral Pathogens

1, 1,* email, 2, 1, 1, 1, 1, 2, 3, 3 and 1
Received: 21 March 2013; in revised form: 16 April 2013 / Accepted: 16 April 2013 / Published: 18 April 2013
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The chemical composition of the essential oils from leaves, bark and wood of Cassia bakeriana Craib. was determined by gas chromatography (GC) and gas chromatography–mass spectrometry (GC-MS). Alcohols, aldehydes and fatty acids were the major components in leaf and bark oil, while wood essential oil was rich in fatty acids. Terpenes such as linalool, (E)-nerolidol and phytol were present in low concentrations. The antimicrobial activity against aerobic and anaerobic oral bacteria was evaluated using the microdilution method, as was the cell viability test carried out with Vero cells. The oils from leaves and bark showed high antimicrobial activity, with minimum inhibitory concentrations between 62.5 and 125 µg·mL−1 for most of the tested bacteria, including Streptococcus mutans, the main etiological agent of dental caries. Leaves oil displayed the lowest cytotoxic effect (EC50 of 153 µg·mL−1), while wood oil exhibited the highest toxicity to Vero cells. C. bakeriana oils are thus a source of biologically active compounds against aerobic and anaerobic oral microorganisms. This study is the first report on the chemical composition, antimicrobial activity and cytotoxicity of C. bakeriana.
Keywords: Cassia bakeriana; essential oil; antimicrobial activity; cytotoxicity
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MDPI and ACS Style

Cunha, L.C.S.; de Morais, S.A.L.; Martins, C.H.G.; Martins, M.M.; Chang, R.; de Aquino, F.J.T.; de Oliveira, A.; Moraes, T.S.; Machado, F.C.; da Silva, C.V.; do Nascimento, E.A. Chemical Composition, Cytotoxic and Antimicrobial Activity of Essential Oils from Cassia bakeriana Craib. against Aerobic and Anaerobic Oral Pathogens. Molecules 2013, 18, 4588-4598.

AMA Style

Cunha LCS, de Morais SAL, Martins CHG, Martins MM, Chang R, de Aquino FJT, de Oliveira A, Moraes TS, Machado FC, da Silva CV, do Nascimento EA. Chemical Composition, Cytotoxic and Antimicrobial Activity of Essential Oils from Cassia bakeriana Craib. against Aerobic and Anaerobic Oral Pathogens. Molecules. 2013; 18(4):4588-4598.

Chicago/Turabian Style

Cunha, Luís C.S.; de Morais, Sérgio A.L.; Martins, Carlos H.G.; Martins, Mário M.; Chang, Roberto; de Aquino, Francisco J.T.; de Oliveira, Alberto; Moraes, Thaís S.; Machado, Fabrício C.; da Silva, Cláudio V.; do Nascimento, Evandro A. 2013. "Chemical Composition, Cytotoxic and Antimicrobial Activity of Essential Oils from Cassia bakeriana Craib. against Aerobic and Anaerobic Oral Pathogens." Molecules 18, no. 4: 4588-4598.

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