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Molecules 2013, 18(4), 3689-3702; doi:10.3390/molecules18043689

Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells

1, 2, 1,* , 2,*  and 1
1 College of Medical, Dalian University, Dalian 116622, China 2 College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, China
* Authors to whom correspondence should be addressed.
Received: 20 December 2012 / Revised: 10 March 2013 / Accepted: 11 March 2013 / Published: 25 March 2013
(This article belongs to the Section Organic Synthesis)
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Monoesters of ginsenoside metabolite M1 at the 3-OH, 4-OH and 6-OH positions of the glucose moiety at M1 were synthesized via the reaction of M1 with acyl chloride, or acid-N,N'-diisopropylcarbodiimide in the presence of DMAP. Their structures were fully characterized by spectral methods. The cytotoxicity of these compounds against then MGC80-3 human gastric cancer cell line was also assessed. High inhibitory effects were found at a concentration of 100 μg/mL.
Keywords: ginsenoside; synthesis; cytotoxicity; MGC80-3 ginsenoside; synthesis; cytotoxicity; MGC80-3
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Li, W.-F.; Chen, L.-R.; Gong, X.-J.; Li, Z.-N.; Li, K.-K. Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells. Molecules 2013, 18, 3689-3702.

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