Molecules 2013, 18(4), 3689-3702; doi:10.3390/molecules18043689
Article

Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells

1, 2, 1,* email, 2,* email and 1
Received: 20 December 2012; in revised form: 10 March 2013 / Accepted: 11 March 2013 / Published: 25 March 2013
(This article belongs to the Section Theoretical Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Monoesters of ginsenoside metabolite M1 at the 3-OH, 4-OH and 6-OH positions of the glucose moiety at M1 were synthesized via the reaction of M1 with acyl chloride, or acid-N,N'-diisopropylcarbodiimide in the presence of DMAP. Their structures were fully characterized by spectral methods. The cytotoxicity of these compounds against then MGC80-3 human gastric cancer cell line was also assessed. High inhibitory effects were found at a concentration of 100 μg/mL.
Keywords: ginsenoside; synthesis; cytotoxicity; MGC80-3
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MDPI and ACS Style

Li, W.-F.; Chen, L.-R.; Gong, X.-J.; Li, Z.-N.; Li, K.-K. Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells. Molecules 2013, 18, 3689-3702.

AMA Style

Li W-F, Chen L-R, Gong X-J, Li Z-N, Li K-K. Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells. Molecules. 2013; 18(4):3689-3702.

Chicago/Turabian Style

Li, Wen-Fang; Chen, Li-Rong; Gong, Xiao-Jie; Li, Zheng-Ning; Li, Ke-Ke. 2013. "Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells." Molecules 18, no. 4: 3689-3702.

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