Molecules 2013, 18(4), 3689-3702; doi:10.3390/molecules18043689
Article

Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells

1 College of Medical, Dalian University, Dalian 116622, China 2 College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, China
* Authors to whom correspondence should be addressed.
Received: 20 December 2012; in revised form: 10 March 2013 / Accepted: 11 March 2013 / Published: 25 March 2013
(This article belongs to the Section Organic Synthesis)
PDF Full-text Download PDF Full-Text [393 KB, uploaded 25 March 2013 15:44 CET]
Abstract: Monoesters of ginsenoside metabolite M1 at the 3-OH, 4-OH and 6-OH positions of the glucose moiety at M1 were synthesized via the reaction of M1 with acyl chloride, or acid-N,N'-diisopropylcarbodiimide in the presence of DMAP. Their structures were fully characterized by spectral methods. The cytotoxicity of these compounds against then MGC80-3 human gastric cancer cell line was also assessed. High inhibitory effects were found at a concentration of 100 μg/mL.
Keywords: ginsenoside; synthesis; cytotoxicity; MGC80-3

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Li, W.-F.; Chen, L.-R.; Gong, X.-J.; Li, Z.-N.; Li, K.-K. Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells. Molecules 2013, 18, 3689-3702.

AMA Style

Li W-F, Chen L-R, Gong X-J, Li Z-N, Li K-K. Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells. Molecules. 2013; 18(4):3689-3702.

Chicago/Turabian Style

Li, Wen-Fang; Chen, Li-Rong; Gong, Xiao-Jie; Li, Zheng-Ning; Li, Ke-Ke. 2013. "Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells." Molecules 18, no. 4: 3689-3702.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert