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• Sanchez-Sanchez, A
• Pérez-Baena, I
• Pomposo, JA.
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• Sanchez-Sanchez, A
• Pérez-Baena, I
• Pomposo, JA.
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• Sanchez-Sanchez, A
• Pérez-Baena, I
• Pomposo, JA.

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Molecules 2013, 18(3), 3339-3355; doi:10.3390/molecules18033339

Review

Advances in Click Chemistry for Single-Chain Nanoparticle Construction

Ana Sanchez-Sanchez ¹ , Irma Pérez-Baena ¹  and José A. Pomposo ^2,3,4,*

¹ Centro de Fisica de Materiales (CSIC, UPV/EHU)-Materials Physics Center, Paseo Manuel de Lardizabal 5, E-20018 San Sebastian, Spain ² Centro de Fisica de Materiales (CSIC, UPV/EHU)-Materials Physics Center, Paseo Manuel de Lardizabal 5, E-20018 San Sebastian, Spain ³ Departamento de Fisica de Materiales, Universidad del Pais Vasco (UPV/EHU), Apartado 1072, E-20080 San Sebastian, Spain ⁴ IKERBASQUE — Basque Foundation for Science, Alameda Urquijo 36, E-48011 Bilbao, Spain

* Author to whom correspondence should be addressed.

Received: 22 February 2013; in revised form: 7 March 2013 / Accepted: 12 March 2013 / Published: 14 March 2013

(This article belongs to the Special Issue Advances in Click Chemistry)

Download PDF Full-Text [358 KB, uploaded 14 March 2013 09:05 CET]

Abstract: Single-chain polymeric nanoparticles are artificial folded soft nano-objects of ultra-small size which have recently gained prominence in nanoscience and nanotechnology due to their exceptional and sometimes unique properties. This review focuses on the current state of the investigations of click chemistry techniques for highly-efficient single-chain nanoparticle construction. Additionally, recent progress achieved for the use of well-defined single-chain nanoparticles in some promising fields, such as nanomedicine and catalysis, is highlighted.

Keywords: click chemistry; controlled polymerization; folding/collapse; single-chain nanoparticles; nanomedicine; catalysis

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