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Molecules 2013, 18(3), 2563-2570; doi:10.3390/molecules18032563

A New Hydroxychavicol Dimer from the Roots of Piper betle

1
Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
2
Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
3
Cell Pharmacology Laboratory, Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
4
Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
5
Department of Dentistry, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
6
Department of Plant Industry, National Pingtung University of Science and Technolog, Pingtung 912, Taiwan
*
Author to whom correspondence should be addressed.
Received: 28 November 2012 / Revised: 8 February 2013 / Accepted: 21 February 2013 / Published: 26 February 2013
(This article belongs to the Section Natural Products)
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Abstract

A new hydroxychavicol dimer, 2-(g'-hydroxychavicol)-hydroxychavicol (1), was isolated from the roots of Piper betle Linn. along with five known compounds, hydroxychavicol (2), aristololactam A II (3), aristololactam B II (4), piperolactam A (5) and cepharadione A (6). The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds 1 and 2 exhibited inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Keywords: Piper betle; 2-(g'-hydroxychavicol)-hydroxychavicol; hydroxychavciol; superoxide anion; elastase; neutrophils Piper betle; 2-(g'-hydroxychavicol)-hydroxychavicol; hydroxychavciol; superoxide anion; elastase; neutrophils
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lin, C.-F.; Hwang, T.-L.; Chien, C.-C.; Tu, H.-Y.; Lay, H.-L. A New Hydroxychavicol Dimer from the Roots of Piper betle. Molecules 2013, 18, 2563-2570.

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