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Molecules 2013, 18(3), 2563-2570; doi:10.3390/molecules18032563
Article

A New Hydroxychavicol Dimer from the Roots of Piper betle

1,2
, 3,4
, 5
, 6
 and 6,*
1 Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan 2 Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan 3 Cell Pharmacology Laboratory, Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan 4 Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan 5 Department of Dentistry, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan 6 Department of Plant Industry, National Pingtung University of Science and Technolog, Pingtung 912, Taiwan
* Author to whom correspondence should be addressed.
Received: 28 November 2012 / Revised: 8 February 2013 / Accepted: 21 February 2013 / Published: 26 February 2013
(This article belongs to the Section Metabolites)
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Abstract

A new hydroxychavicol dimer, 2-(g'-hydroxychavicol)-hydroxychavicol (1), was isolated from the roots of Piper betle Linn. along with five known compounds, hydroxychavicol (2), aristololactam A II (3), aristololactam B II (4), piperolactam A (5) and cepharadione A (6). The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds 1 and 2 exhibited inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Keywords: Piper betle; 2-(g'-hydroxychavicol)-hydroxychavicol; hydroxychavciol; superoxide anion; elastase; neutrophils Piper betle; 2-(g'-hydroxychavicol)-hydroxychavicol; hydroxychavciol; superoxide anion; elastase; neutrophils
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lin, C.-F.; Hwang, T.-L.; Chien, C.-C.; Tu, H.-Y.; Lay, H.-L. A New Hydroxychavicol Dimer from the Roots of Piper betle. Molecules 2013, 18, 2563-2570.

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