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A New Hydroxychavicol Dimer from the Roots of Piper betle
Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
Cell Pharmacology Laboratory, Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
Department of Dentistry, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Department of Plant Industry, National Pingtung University of Science and Technolog, Pingtung 912, Taiwan
* Author to whom correspondence should be addressed.
Received: 28 November 2012; in revised form: 8 February 2013 / Accepted: 21 February 2013 / Published: 26 February 2013
Abstract: A new hydroxychavicol dimer, 2-(g'-hydroxychavicol)-hydroxychavicol (1), was isolated from the roots of Piper betle Linn. along with five known compounds, hydroxychavicol (2), aristololactam A II (3), aristololactam B II (4), piperolactam A (5) and cepharadione A (6). The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds 1 and 2 exhibited inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Keywords: Piper betle; 2-(g'-hydroxychavicol)-hydroxychavicol; hydroxychavciol; superoxide anion; elastase; neutrophils
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Lin, C.-F.; Hwang, T.-L.; Chien, C.-C.; Tu, H.-Y.; Lay, H.-L. A New Hydroxychavicol Dimer from the Roots of Piper betle. Molecules 2013, 18, 2563-2570.
Lin C-F, Hwang T-L, Chien C-C, Tu H-Y, Lay H-L. A New Hydroxychavicol Dimer from the Roots of Piper betle. Molecules. 2013; 18(3):2563-2570.
Lin, Chwan-Fwu; Hwang, Tsong-Long; Chien, Chun-Chien; Tu, Huei-Yu; Lay, Horng-Liang. 2013. "A New Hydroxychavicol Dimer from the Roots of Piper betle." Molecules 18, no. 3: 2563-2570.